AGING UPON CORTICAL FUNCTION IN MONKEYS

猴子皮质功能的衰老

• 批准号: 2706112
• 负责人: Audie Leventhal
• 金额: $ 7.48万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2706112
• 关键词: Macaca mulatta; age difference; aging; computer data analysis; cytochrome oxidase; histochemistry /cytochemistry; lateral geniculate body; neural information processing; retinal ganglion; space perception; visual cortex; visual fields; visual pathways; visual perception

Human visual function declines with age. A significant body of evidence suggests that much of this decline is associated with neuronal changes in the central visual pathways. The purpose of this proposal is, for the first time, to compare the functional organization of visual cortex and retina in young and old monkeys. The effects of aging upon the two main visual processing streams that comprise the primate retinogeniculocortical pathways will be studied. Two experiments are proposed in order to determine the neuronal bases of the age related decline in visual function that accompanies normal aging. These are outlined below. Experiment 1 will compare, in young and old monkeys, the receptive field properties of cells in cortical areas V1 (striate cortex) and V2. The properties to be studied include spatial resolution, contrast sensitivity, linearity of response, velocity sensitivity, binocularity, orientation sensitivity, direction sensitivity, wavelength sensitivity, receptive field size, receptive field organization (on and off sub- fields), response latency and response variability. The laminar locations of the cells studied will be determined as will their locations within functional compartments defined be cytochrome oxidase staining. Age related changes in receptive field properties will be related to the well documented declines in visual function associated with normal aging (see background ana significance). Experiment 2 will compare, in young and old monkeys, the properties of the two main morphological classes of retinal ganglion cells (M and P cells) projecting to the dorsal lateral geniculate nucleus. The cell body sizes, dendritic field structures, and retinal distributions of M and P cells will be studied quantitatively. The PI has been studying the morphology and receptive field properties of neurons in the mammalian visual pathways for twenty five years. The techniques required to carry out the proposed studies are constantly in use in his laboratory. In most cases, control data from normal animals has already been collected as a result of previous work. The proposed studies , thus, will undoubtedly yield valuable, clinically relevant data.

人类的视觉功能随着年龄的增长而下降。 大量证据 表明这种下降的大部分与神经元变化有关 在中央视觉途径中。 该提议的目的是 第一次比较视觉皮层的功能组织 和小猴子的视网膜。 衰老对两者的影响 主要的视觉处理流构成灵长类动物 将研究视网膜生成皮层途径。 两个实验是 提出的目的是确定与年龄相关的神经元基础 正常衰老伴随的视觉功能下降。这些都是 下面概述了。 实验1将在年轻人和老猴子中比较接受场 皮质区域V1（阶段皮层）和V2中细胞的性质。 这 要研究的属性包括空间分辨率，对比度 灵敏度，响应的线性，速度灵敏度，双向性，双向性， 方向灵敏度，方向灵敏度，波长灵敏度， 接受场大小，接受野外组织（在 字段），响应延迟和响应变异性。 层流 研究的细胞的位置将被确定 功能区室内定义的位置是细胞色素氧化酶 染色。年龄相关的接受场特性的变化将是 与有据可视的视觉功能下降有关 正常老化（请参阅背景ANA意义）。 实验2将在年轻人和老猴子中比较 视网膜神经节细胞的两个主要形态学类别（M和P 细胞）投射到背侧侧向核的核。 细胞 M的身体大小，树突状田地结构和M的视网膜分布 和P细胞将进行定量研究。 PI一直在研究 哺乳动物中神经元的形态和接受田间特性 视觉途径二十五年。 携带所需的技术 拟议的研究经常在他的实验室中使用。 在 大多数情况下，已经收集了来自正常动物的控制数据 由于以前的工作。 因此，提出的研究将 无疑会产生有价值的临床相关数据。