Age-related changes in proprioceptive acuity

本体感觉敏锐度与年龄相关的变化

• 批准号: 7106529
• 负责人: SUSAN H BROWN
• 金额: $ 5.89万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106529
• 关键词: age difference; aging; arm; body physical activity; clinical research; exercise; functional ability; hand; handedness; human old age (65+); human subject; limb movement; muscle strength; neuromuscular function; proprioception /kinesthesia; sensorimotor system; statistics /biometry

DESCRIPTION (provided by applicant): Aging is associated with a decline in motor ability which has been typically described in terms of muscle weakness leading to postural instability and locomotor difficulties. In contrast, our understanding of how age-related changes in somatosensory feedback affects motor function is remarkably poor. This is particularly true for the upper limbs despite the importance of arm and hand use in many activities of daily activity and the maintenance of functional independence. In particular, proprioceptive feedback arising from muscle stretch, cutaneous, and force receptors is critical not only in providing an awareness of body position, but in the generation, learning, and on-going control of goal-directed limb movements. Given the paucity of data in this area, the aims of this study are: 1) to provide much needed baseline information regarding upper limb proprioceptive acuity in older individuals and to determine whether changes in motor function are related to changes in proprioceptive function, 2) to determine whether physical activity impacts proprioceptive acuity in older individuals, and 3) to determine if proprioceptive acuity differs between the dominant and non-dominant hands. Young (20-30 yrs) and two groups of elderly subjects 70 yrs and older (sedentary vs active) will be examined. Wrist position and hand grasp force matching paradigms will be used in which movements/forces are produced based solely on limb position or force reference information. Matching tasks will vary in complexity by requiring subjects to match the movement or force with the same or opposite limb. Instrumented levers and force transducers will be used to measure wrist movement and grasp force, respectively. In the limb matching conditions, a servomotor will be used to passively displace the joint at a constant slow velocity. This study will form the foundation for a longer-term research program examining sensorimotor function in the elderly, including disease conditions which impact mobility, and with a focus on maintenance and/or improvement in upper limb function through, for example, training-based interventions.

描述（由申请人提供）：衰老与运动能力下降相关，这通常被描述为导致姿势不稳定和运动困难的肌肉无力。相比之下，我们对与年龄相关的体感反馈变化如何影响运动功能的理解非常贫乏。尽管手臂和手的使用在许多日常活动和维持功能独立性中很重要，但对于上肢来说尤其如此。特别是，由肌肉拉伸、皮肤和力感受器产生的本体感觉反馈不仅对于提供身体位置的感知至关重要，而且对于目标导向的肢体运动的生成、学习和持续控制也至关重要。鉴于该领域数据匮乏，本研究的目的是：1）提供有关老年人上肢本体感觉敏锐度的急需基线信息，并确定运动功能的变化是否与本体感觉功能的变化相关，2）确定身体活动是否影响老年人的本体感觉敏锐度，以及 3) 确定优势手和非优势手之间的本体感觉敏锐度是否存在差异。将对年轻人（20-30 岁）和两组 70 岁及以上的老年受试者（久坐与活跃）进行检查。将使用手腕位置和手抓力匹配范例，其中仅基于肢体位置或力参考信息来产生运动/力。匹配任务的复杂性会有所不同，要求受试者将运动或力量与相同或相反的肢体相匹配。仪表化杠杆和力传感器将分别用于测量手腕运动和抓握力。在肢体匹配条件下，伺服电机将用于以恒定的低速被动地移动关节。这项研究将为一项检查老年人感觉运动功能的长期研究计划奠定基础，包括影响活动能力的疾病状况，并重点通过基于训练的干预措施等来维持和/或改善上肢功能。