FACILITATION OF MOTOR FUNCTION THROUGH SENSORY CUEING

通过感官提示促进运动功能

• 批准号: 2769330
• 负责人: SUSAN H BROWN
• 金额: $ 9.95万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769330
• 关键词: Parkinson's disease; age difference; aging; arm; auditory stimulus; basal ganglia; behavioral /social science research tag; clinical research; computer program /software; cues; degenerative motor system disease; electromyography; human old age (65+); human subject; limb movement; performance; rehabilitation; sensorimotor system; visual stimulus; young adult human (21-34)

The studies in this application focus on the use of rhythmic sensory stimuli to improve motor performance in chronic motor dysfunction conditions. Two population groups characterized by progressive loss in the ability to coordinate complex movements will be examined: (1) idiopathic Parkinson's Disease patients of 3-5 years duration with decreased responsiveness to L-Dopa therapy and (2) healthy elderly subjects. Specific aims will (1) compare the effectiveness of auditory versus visual stimuli in facilitating movement sequencing, (2) identify motor tasks most responsive to sensory cueing and (3) establish a framework for the future development of effective rehabilitative techniques using rhythmic sensory cueing to improve motor performance in a variety of motor dysfunction conditions. These studies will also provide valuable insights into the mechanisms by which temporal information is utilized by the central nervous system in movement planning and execution and how such sensorimotor transformations are disrupted with aging and in Parkinson's Disease. Auditory, visual and combined auditory-visual stimuli will be used as external timing cues during the generation of rhythmic, sequential arm movements. Motor tasks will include unilateral and bilateral movements in which task complexity will be modified by manipulation of spatio-temporal parameters. By examining a broad repertoire of movements, it will be possible to delineate those motor tasks most sensitive to sensory cueing. Decreased variability in movement duration and end-point position as well as task-specific improvement in speed and inter limb coordination will serve as functional outcome measures of sensory facilitation in the production of sequential motor tasks. Enhanced control of movement dynamics will be assessed by examining changes in the relationship between joint angular rotation, movement trajectories and timing of opposing muscle groups. A three dimensional motion analysis system and surface electromyography will be used to obtain kinematic and muscle activity data. All data will be collected on-line and interactive computer software will be used for off-line quantification. These studies represent a unique cross-disciplinary approach to movement rehabilitation by combining expertise in motor physiology, physical medicine and neurology and will be the first in-depth, quantitative evaluation of sensory enhanced motor performance in elderly subjects and Parkinson's Disease.

该应用中的研究重点是使用节奏感官 刺激以改善慢性运动功能障碍的运动性能 状况。两个人口群体以进行性损失为特征 将检查协调复杂运动的能力：（1） 特发性帕金森氏病患者3 - 5年 对L-DOPA疗法的反应性降低和（2）健康的老年人 主题。具体目标将（1）比较听觉的有效性 与视觉刺激相对于促进运动测序的视觉刺激，（2）确定 电机任务对感官提示的响应最敏感，（3）建立一个 有效康复的未来发展框架 使用节奏感官提示的技术来提高运动性能 各种电动机功能障碍条件。这些研究也将 提供有关暂时性的机制的宝贵见解 中枢神经系统在运动中使用了信息 计划和执行以及这种感觉运动转换的方式 因衰老和帕金森氏病而破坏。 听觉，视觉和合并的听觉 - 视觉刺激将被用作 节奏，顺序臂的外部时间提示 动作。运动任务将包括单侧和双侧运动 通过操纵将修改任务复杂性 时空参数。通过检查广泛的运动曲目， 可以描绘那些对那些最敏感的运动任务 感官提示。 运动持续时间和终点位置的变化降低 随着任务特定的速度和肢体间协调的改进将 作为感官促进的功能结果度量 产生顺序运动任​​务。增强运动的控制 动态将通过检查关系的变化来评估 在关节角旋转，运动轨迹和时间之间 反对肌肉群。三维运动分析系统和 表面肌电图将用于获得运动学和肌肉 活动数据。所有数据将在线收集和交互式 计算机软件将用于离线量化。 这些研究代表了一种独特的跨学科运动方法 通过结合运动生理学专业知识，身体的康复 医学和神经病学将是第一个深入的定量 评估老年受试者的感觉增强运动性能的评估 帕金森氏病。