FACILITATION OF MOTOR FUNCTION THROUGH SENSORY CUEING

通过感官提示促进运动功能

• 批准号: 6055387
• 负责人: SUSAN H BROWN
• 金额: $ 8.97万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6055387
• 关键词: Parkinson's disease; age difference; aging; arm; auditory stimulus; basal ganglia; behavioral /social science research tag; clinical research; computer program /software; cues; degenerative motor system disease; electromyography; human old age (65+); human subject; limb movement; medical rehabilitation related tag; performance; rehabilitation; sensorimotor system; visual stimulus; young adult human (21-34)

The studies in this application focus on the use of rhythmic sensory stimuli to improve motor performance in chronic motor dysfunction conditions. Two population groups characterized by progressive loss in the ability to coordinate complex movements will be examined: (1) idiopathic Parkinson's Disease patients of 3-5 years duration with decreased responsiveness to L-Dopa therapy and (2) healthy elderly subjects. Specific aims will (1) compare the effectiveness of auditory versus visual stimuli in facilitating movement sequencing, (2) identify motor tasks most responsive to sensory cueing and (3) establish a framework for the future development of effective rehabilitative techniques using rhythmic sensory cueing to improve motor performance in a variety of motor dysfunction conditions. These studies will also provide valuable insights into the mechanisms by which temporal information is utilized by the central nervous system in movement planning and execution and how such sensorimotor transformations are disrupted with aging and in Parkinson's Disease. Auditory, visual and combined auditory-visual stimuli will be used as external timing cues during the generation of rhythmic, sequential arm movements. Motor tasks will include unilateral and bilateral movements in which task complexity will be modified by manipulation of spatio-temporal parameters. By examining a broad repertoire of movements, it will be possible to delineate those motor tasks most sensitive to sensory cueing. Decreased variability in movement duration and end-point position as well as task-specific improvement in speed and inter limb coordination will serve as functional outcome measures of sensory facilitation in the production of sequential motor tasks. Enhanced control of movement dynamics will be assessed by examining changes in the relationship between joint angular rotation, movement trajectories and timing of opposing muscle groups. A three dimensional motion analysis system and surface electromyography will be used to obtain kinematic and muscle activity data. All data will be collected on-line and interactive computer software will be used for off-line quantification. These studies represent a unique cross-disciplinary approach to movement rehabilitation by combining expertise in motor physiology, physical medicine and neurology and will be the first in-depth, quantitative evaluation of sensory enhanced motor performance in elderly subjects and Parkinson's Disease.

本申请的研究重点是节奏感觉的使用 刺激改善慢性运动功能障碍的运动表现 状况。两个人口群体的特征是逐渐丧失 将检查协调复杂运动的能力：（1） 病程 3-5 年的特发性帕金森病患者 对左旋多巴治疗的反应降低和 (2) 健康老年人 科目。具体目标将（1）比较听觉的有效性 与视觉刺激在促进运动排序方面的比较，(2) 识别 运动任务对感觉提示最敏感，并且（3）建立一个 未来发展有效康复的框架 使用有节奏的感觉提示来提高运动表现的技术 各种运动功能障碍的情况。这些研究也将 为时间机制提供有价值的见解 中枢神经系统在运动中利用信息 计划和执行以及这种感觉运动转变是如何进行的 随着衰老和帕金森病的发生而受到干扰。 听觉、视觉和听觉视觉组合刺激将被用作 有节奏的顺序臂生成过程中的外部时序提示 动作。运动任务将包括单边和双边运动 其中任务复杂性将通过操纵来修改 时空参数。通过检查广泛的动作， 将有可能描绘出那些对最敏感的运动任务 感官提示。 运动持续时间和终点位置的可变性也减少 因为特定任务的速度和肢体间协调性的提高将 作为感官促进的功能性结果测量 顺序运动任​​务的产生。增强运动控制 将通过检查关系的变化来评估动态 关节角旋转、运动轨迹和时间之间 对立的肌肉群。三维运动分析系统和 表面肌电图将用于获得运动学和肌肉 活动数据。所有数据都将在线收集并交互 计算机软件将用于离线量化。 这些研究代表了一种独特的跨学科运动方法 结合运动生理学、物理学等方面的专业知识进行康复 医学和神经病学，并将是第一个深入、定量的 评估老年受试者的感觉增强运动表现 帕金森病。