Plasticity of motor cortical preferred directions

运动皮质首选方向的可塑性

• 批准号: 7199301
• 负责人: BEATA JAROSIEWICZ
• 金额: $ 4.88万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7199301
• 关键词: Plasticity; motor; cortical; preferred; directions

DESCRIPTION (provided by applicant): The finding that neurons "encode" various facets of the world was fundamental to our understanding of brain function; the finding that neural coding is plastic is a fundamental principal of nearly equal magnitude. There is a limit to the amount of information that can be gleaned about the mechanisms and meaning of functional plasticity using traditional methods that induce learning and examine the resulting changes in the brain. Using the motor neural prosthetics paradigm, it is possible to control the functional consequence of the firing activity of a group of cells; thus, it is possible to directly change the mapping from the spiking activity of a subset of cells to its effects on the external world. The proposed experiments would address the following questions: 1) To what extent can the motor cortex compensate for changes in the mapping between the activity of a subset of its neurons and the consequences of its activity on the external world? 2) Are different compensation strategies used when different amounts of change are imposed? 3) How selective is the brain in changing the firing correlates of the particular cells whose mapping was changed? A investigation of these issues will reveal insights about the system-level mechanisms of plasticity in a way not possible with traditional methods.

描述（由申请人提供）：神经元“编码”世界各个方面的发现是我们对大脑功能的理解至关重要的。神经编码是塑性的发现是几乎相等的基本原理。可以使用传统方法诱导学习并检查大脑所产生的变化的功能可塑性的机制和含义的信息量限制。使用运动神经假体范式，可以控制一组细胞发射活性的功能后果。因此，有可能将映射从一个子集的尖峰活动直接更改为对外部世界的影响。拟议的实验将解决以下问题：1）运动皮层可以在多大程度上补偿其神经元的活动的活动与其对外部世界的活动的后果之间的映射变化？ 2）当施加不同数量的变更时，是否使用了不同的补偿策略？ 3）大脑在更改映射的特定单元格的发射相关性方面的选择性如何？对这些问题的调查将揭示有关传统方法不可能以某种方式进行有关可塑性机制的见解。