Acoustic Radiation Force Imaging of Arteries

动脉声辐射力成像

• 批准号: 6970885
• 负责人: Gregg E. Trahey
• 金额: $ 37.07万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6970885
• 关键词: angiography; atherosclerosis; atherosclerotic plaque; bioimaging /biomedical imaging; biological models; biomechanics; cardiovascular disorder risk; clinical research; computer simulation; elasticity; electrocardiography; heart contraction; human subject; image processing; model design /development; radiation; technology /technique development; time resolved data; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): We have developed a new method of imaging the mechanical properties of tissues based on very brief (< 1ms) and localized applications of acoustic radiation force and the ultrasonic measurement of the associated tissues' responses to that force. Initial results with this technique demonstrate its ability to image mechanical properties of the medial and adventitial layers within ex vivo and in vivo arteries, and to distinguish hard and soft atherosclerotic plaques from normal vessel wall. We have labeled this method Acoustic Radiation Force Impulse (ARFI) imaging, and are poised to develop a real-time ARFI imaging system utilizing a modified commercial ultrasonic scanner and transducers. We propose studies to develop and evaluate this new technique in the characterization of diffuse and focal atherosclerosis. We propose phantom trials and finite element simulations to guide signal acquisition and processing methods, to explore the fundamental issues of resolution and contrast, and to derive mechanical properties from tissue responses to ARFI excitations containing both inertial and viscoelastic components. We propose ex vivo and in vivo trials in the popliteal and femoral arteries to assess the relationship between the mechanical properties of healthy and diseased arteries provided by this new method and those obtained by alternative methods. We propose clinical trials to assess the relationship between ARFI-derived measures of vascular disease and other methods based on ultrasonic imaging and physical examinations.

描述（由申请人提供）： 我们开发了一种新的组织机械特性成像方法，该方法基于非常短暂（< 1ms）和局部的声辐射力应用以及相关组织对该力的响应的超声波测量。该技术的初步结果表明，其能够对离体和体内动脉内的内侧和外膜层的机械特性进行成像，并区分硬动脉粥样硬化斑块和软动脉粥样硬化斑块与正常血管壁。我们将这种方法标记为声辐射力脉冲 (ARFI) 成像，并准备利用改进的商用超声波扫描仪和换能器开发实时 ARFI 成像系统。我们建议进行研究来开发和评估这种新技术在弥漫性和局灶性动脉粥样硬化的表征中的作用。我们提出模型试验和有限元模拟来指导信号采集和处理方法，探索分辨率和对比度的基本问题，并从组织对包含惯性和粘弹性成分的 ARFI 激励的响应中得出机械特性。我们建议在腘动脉和股动脉中进行离体和体内试验，以评估这种新方法提供的健康和患病动脉的机械特性与通过替代方法获得的机械特性之间的关系。我们建议进行临床试验来评估 ARFI 衍生的血管疾病测量方法与基于超声成像和体检的其他方法之间的关系。