PROJECT 1: CORE COMPONENT OF THE TRAUMA CENTER - ANIMAL CORE III: MAST CELLS

项目 1：创伤中心的核心组成部分 - 动物核心 III：肥大细胞

• 批准号: 7551120
• 负责人: MICHAEL F GURISH
• 金额: $ 7.89万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7551120
• 关键词: animal care; biomedical facility; complement; immunoglobulin M; injury; intestines; ischemia; mast cell; reperfusion; striated muscles

This animal core will provide the mice necessary to study the role of the mast cell (MC) and its mediators in the local and remote injury that occurs |ollowing ischemic-reperfusion in the either the skeletal muscle or in the intestine. These studies use numerous spontaneous and genetically engineered mice lacking specific cells or mediators implicated in the local tissue and remote lung injury associated with ischemia-reperfusion in the skeletal muscle or intestine. It will also provide the support for investigating the interaction between the MC, the complement system and natural IgM, all of which are implicated in the pathobiology of ischemiareperfusion. Finally it will provide the support to define the mechanism of preconditioning protection against ischemia-reperfusion injury.

该动物核心将为研究肥大细胞（MC）及其介质在骨骼肌或肠道缺血再灌注后发生的局部和远程损伤中的作用提供必要的小鼠。这些研究使用大量自发的基因工程小鼠，这些小鼠缺乏与骨骼肌或肠道缺血再灌注相关的局部组织和远端肺损伤相关的特定细胞或介质。它还将为研究 MC、补体系统和天然 IgM 之间的相互作用提供支持，所有这些都与缺血再灌注的病理学有关。最后将为明确缺血再灌注损伤的预处理保护机制提供支持。