Center for Interdisciplinary Health Disparities Research

跨学科健康差异研究中心

• 批准号: 7294847
• 负责人: SARAH Jane GEHLERT
• 金额: $ 19.06万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-18 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7294847
• 关键词: behavioral /social science research tag; breast neoplasms; clinical research; health disparity; health services research tag

The specific aims of the Center for Interdisciplinary Health Disparities Research are to: Aim #1: bring together scientists from inside and outside the University and members of the community who are especially vulnerable to adverse health conditions to inform the Center's scientific agenda; Aim #2: foster investigations that consider health disparities from multiple levels of analysis via shared conceptual frameworks that integrate discipline-specific theories and methods; Aim #3: increase interest in health disparities among scientist and students from various disciplines and from community members; Aim #4: develop measures and methods that are appropriate for use with vulnerable populations and that allow factors at various levels (social/environmental, behavioral/psychological, and biological/genetic) to be analyzed together; Aim #5: increase existing knowledge on the social, behavioral, and biological factors that influence health disparities and the nature of their interactions; and, Aim #6: disseminate findings through channels established through the Center to as wide an audience as possible, including members of vulnerable populations, community-based organizations and agencies, and scientific investigators inside and outside the University. In its first five years, the Center will focus on group differences in breast cancer, notably why Black women in the US and West Africa experience breast cancers that occur at a younger age and are more aggressive and lethal than those of White women. McClintock (R01 # 1), based on an animal model of social regulation of mammary tumor biology developed in her laboratory, will compare the gene regulation in mammary tumors and the ovarian function of socially isolated and group-living rats. OIopade (R01# 2) will (a) look at the molecular characterization of primary patient samples in Nigeria and Chicago's South Side to see if alterations in BRCA1 contribute to breast cancer in younger Black women and (b) explore the McClintock model in primary patient samples. Gehlert and Masi (R01# 3; CBPR) will explore emic views of breast cancer and its treatment and test the McClintock model with community volunteers. In the lalffer, they will examine neighborhood and community factors (such as collective efficacy and crime), living situations and social connectedness, behavioral responses (such as vigilance and perceived stress), and biological (e.g., cortisol levels) and health outcomes (most notably breast cancer). Conzen (R01# 4) will study rate of mammary tumor growth, response to chemotherapy, and chemoprevention in two animal models. The Tissue Core will provide analysis of mammary tissue. Coordination and dissemination will occur through the Administrative Core, by means of Faculty Colloquium and Monthly Speaker Series, In-Service and Summer Apprenticeship programs, a Center Web site and Web page for communication with other CPHHDs, etc.

跨学科健康差异中心研究的具体目的是：AIM＃1：将大学内外的科学家和社区成员组合在一起，他们特别容易受到不利健康状况的影响，以告知该中心的科学议程； AIM＃2：通过共享概念框架从多个分析中考虑健康差异的调查，这些概念框架整合了纪律特定的理论和方法；目标＃3：增加来自各个学科和社区成员的科学家和学生对健康差异的兴趣；目标＃4：制定适合与弱势群体一起使用的措施和方法，并允许在不同层面（社会/环境，行为/心理和生物学/遗传）的因素 一起分析；目标＃5：增加有关影响健康差异及其互动性质的社会，行为和生物学因素的现有知识；并且，目标＃6：通过通过中心建立的渠道传播发现，以尽可能广泛的受众，包括弱势群体，社区组织和机构的成员以及大学内外的科学研究人员。 在头五年中，该中心将重点关注乳腺癌的群体差异，尤其是为什么美国和西非的黑人妇女会经历年轻时发生的乳腺癌，并且比白人妇女更具侵略性和致命性。 McClintock（R01＃1）基于在她的实验室开发的乳腺肿瘤生物学的社会调节模型，将比较乳腺肿瘤的基因调节以及社会分离和群体生存的大鼠的卵巢功能。 OIOPADE（R01＃2）将（a）探讨尼日利亚和芝加哥南侧原代患者样品的分子表征，以查看BRCA1的改变是否有助于年轻的黑人妇女的乳腺癌，（b）探索主要患者样品中的McClintock模型。 Gehlert和Masi（R01＃3; CBPR）将探索乳腺癌及其治疗的观点，并与社区志愿者一起测试McClintock模型。在拉尔弗（Lalffer）中，他们将检查社区和社区因素（例如集体效力和犯罪），生活状况和社会联系，行为反应（例如警惕和感知到的压力）以及生物学（例如皮质醇水平）和健康成果（最值得注意的是乳腺癌）。 Conzen（R01＃4）将研究两个动物模型中乳腺肿瘤生长，对化疗的反应和化学预防的速率。组织核心将提供乳腺组织的分析。通过教师座谈会和每月发言人系列，在职和夏季学徒制，协调和传播将通过行政核心进行 程序，中心网站和网页，用于与其他CPHHD进行通信，等等。