Sleep-wake disturbances in breast cancer survivors

乳腺癌幸存者的睡眠-觉醒障碍

• 批准号: 7110537
• 负责人: JULIE L Otte
• 金额: $ 2.92万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-02 至 2009-05-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110537
• 关键词: actigraphy; behavioral /social science research tag; breast neoplasms; clinical research; environmental stressor; female; hot flash; human subject; predoctoral investigator; prognosis; psychological aspect of cancer; psychophysiology; questionnaires; sleep deprivation; sleep disorders; women' s health

DESCRIPTION (provided by applicant): Sleep-wake disturbances, defined as disruptions in nocturnal rest that result in daytime physical, psychological, and/or social dysfunction, are a significant problem for breast cancer survivors (BCS). Consequences of sleep-wake disturbances can be immediate or delayed, affecting general physiological, social and/or emotional functioning. However, it is unclear whether the prevalence of sleep-wake disturbances differs between BCS and healthy women. In addition, there is a lack of knowledge regarding the relationships among predictors of sleep-wake disturbances in BCS and healthy women (HW). Lack of knowledge of predictors of sleep-wake disturbances and how they may differ from predictors in HW makes it difficult to design and target interventions specifically for BCS. Therefore, this training plan and research will investigate and compare sleep-wake disturbances and their predictors in BCS and HW. The central aims and hypotheses will be tested using standardized self-report questionnaires and objective measurement (wrist actigraph). Specific aims are as follows: Aim 1: To compare sleep-wake disturbances between BCS and HW; Aim 2: To determine predictors of sleep-wake disturbances in BCS and HW; Aim 3: To determine whether predictors of sleep-wake disturbances differ between BCS and HW.

描述（由申请人提供）：睡眠效果障碍定义为夜间休息中的中断，导致白天的身体，心理和/或社交功能障碍，这对于乳腺癌幸存者（BCS）来说是一个重大问题。睡眠效果干扰的后果可能是立即或延迟的，影响一般的生理，社会和/或情绪功能。但是，目前尚不清楚BCS和健康女性之间的睡眠效果障碍的患病率是否有所不同。此外，关于BCS和健康妇女（HW）的睡眠效果预测指标之间的关系缺乏知识。缺乏对睡眠效果障碍预测指标的知识及其与HW中的预测因子的不同，因此很难专门设计和针对BCS的干预措施。因此，该培训计划和研究将在BCS和HW中调查和比较睡眠效果障碍及其预测因素。中心目的和假设将使用标准化的自我报告问卷和客观测量（手腕行为）进行检验。具体目的如下：目标1：比较BCS和HW之间的睡眠效果障碍；目标2：确定BCS和HW中睡眠效果干扰的预测因素； AIM 3：确定BCS和HW之间的睡眠效果障碍的预测因素是否有所不同。