Accuracy of Physical Activity Measures in Cancer Studies

癌症研究中身体活动测量的准确性

• 批准号: 6928380
• 负责人: BARBARA STERNFELD
• 金额: $ 41.61万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6928380
• 关键词: actigraphy; automated data processing; behavioral /social science research tag; body composition; body physical activity; breast neoplasms; cancer risk; clinical research; data collection methodology /evaluation; human subject; interview; patient oriented research; personal log /diary; prostate neoplasms; statistics /biometry

DESCRIPTION (provided by applicant): Methodological challenges inherent in the assessment of physical activity in epidemiological studies introduce measurement errors that limit our understanding of the role of physical activity in reducing the risk of cancer and other diseases. The primary goal of this proposal is to identify and quantify the measurement error associated with two self administered physical activity (PA) questionnaires used to assess recent activity in two on-going cancer cohort studies (Life After Cancer Epidemiology Study, funded by the NCI, and the California Men's Health Study, funded by the California Cancer Research Program). To achieve this goal, we propose to conduct a validation study involving comparisons of the two test questionnaires with 1) 14 days of physical activity diaries (2 7-day periods, 5-6 months apart); 2) 14 days of accelerometer recordings, simultaneous with the PA diaries; 3) aerobic capacity as determined from a sub-maximal graded exercise treadmill test; and 4) body size measurements (body mass index, % body fat from bioelectric impedance, and waist circumference). The validation study will also include evaluation of 2-4 week test-retest repeatability of the two questionnaires. The study participants will be randomly drawn from the Northern California Kaiser Permanente (KP) Cancer Registry and general membership files and will consist of 400 women and men, ages 45-65, diagnosed with breast or prostate cancer 24-36 months prior to recruitment, and 400 women and men of similar age but with no history of cancer. The sample is expected to reflect the racial/ethnic diversity of the KP membership. In addition, we propose to develop an application program for a hand-held computer (personal digital assistant or PDA) that will be used for the collection and management of the PA diaries. We will evaluate the comparability of the PA diaries collected on the PDAs with traditional paper and pen diaries in a pilot study prior to the validation study. For the pilot study, 50 men and women, randomly drawn from the same sampling frame to be used in the validation study, will record their activities for a 4-day period in each of 3 consecutive weeks, with half using PDAs for two of the periods and paper and pen for one period, and the other half doing the reverse. The pilot study participants will also complete a cognitive interview to provide insights into the usability of the PDA software and the thought processes required in the recall of physical activity by the two test questionnaires. Sources of measurement error in the questionnaires will be identified and quantified, and statistical methods for adjusting for measurement error will be applied to the parent studies to estimate the risk of disease (breast cancer recurrence or incident prostate cancer) associated with physical activity. Because the validation will be conducted in a large, diverse, randomly selected sample, the findings may be potentially generalizable to other studies of physical activity and cancer, and may have broad applicability for studies of physical activity and other health outcomes as well.

描述（由申请人提供）：流行病学研究中体育活动评估固有的方法论挑战引入了测量误差，这限制了我们对体育活动在减少癌症和其他疾病风险中的作用的理解。该提案的主要目的是识别和量化与两种自我管理的体育活动（PA）问卷相关的测量误差（PA）问卷，用于评估两项正在进行的癌症队列研究的最新活动（癌症流行病学研究后，由NCI资助，由加利福尼亚男性健康研究资助，由加利福尼亚癌症研究计划资助）。为了实现这一目标，我们建议进行一项验证研究，涉及两种测试问卷与1）14天的体育活动日记（2 7天，相隔5-6个月）进行比较。 2）14天的加速度计记录，同时与PA日记同时记录； 3）根据亚最大分级运动跑步机测试确定的有氧能力； 4）体型测量值（体重指数，生物电阻抗中的体内脂肪％和腰围）。验证研究还将包括对两项问卷的2-4周重复重复性的评估。该研究参与者将随机从北加州Kaiser Permanente（KP）癌症注册表和一般会员档案中吸引，并由400名45-65岁的男性和男性组成，这些男女在招募前24-65个月被诊断出患有乳腺癌或前列腺癌，400名男性和男性相似，但没有癌症的病史。该样本有望反映KP成员的种族/族裔多样性。此外，我们建议为手持计算机（个人数字助理或PDA）制定申请程序，该程序将用于收集和管理PA Diaries。在验证研究之前，我们将在PDA上与传统纸和笔记一起在PDA上收集的PA日记的可比性。在试点研究中，从相同的抽样框架中随机绘制的50名男性和女性将连续3周内每隔4天记录其活动，其中一半使用PDA在两个时期和纸和笔中使用一个时期，而另一半则进行反向。试点研究参与者还将完成认知访谈，以提供有关PDA软件的可用性以及两项测试问卷进行体育活动所需的思维过程的见解。将确定和量化问卷中的测量误差来源，并将调整测量误差的统计方法应用于父母研究，以估计与体育活动相关的疾病（乳腺癌复发或入射前列腺癌）的风险。由于该验证将以大型，多样化的随机选择样本进行，因此这些发现可能可以推广到其他关于体育活动和癌症的研究，并且可能对体育活动和其他健康结果的研究具有广泛的适用性。