Cortical Connectivity Using Magnetic Source Imaging

使用磁源成像的皮质连接

• 批准号: 7036561
• 负责人: SARANG S DALAL
• 金额: $ 2.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-19 至 2007-03-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7036561
• 关键词: bioimaging /biomedical imaging; biophysics; brain electrical activity; brain mapping; brain neoplasms; cerebral cortex; clinical research; electrocorticography; human subject; magnetic resonance imaging; magnetoencephalography; method development; neural information processing; phonology; predoctoral investigator; speech

DESCRIPTION (provided by applicant): The scientific goal of this project is to use magnetoencephalography (MEG) to gain a better understanding of the cortical networks involved in phonetic processing. Cortical sources involved in phonetic processing using whole-head MEG shall be investigated using novel tools to reconstruct their locations and time courses. Key technical developments to facilitate this work include methods to co-register and normalize MEG, ECoG, and structural MRI data. Cortical network connectivity during phonetic processing will also be examined using neural source reconstructions. To the extent possible, all analyses will be cross-validated with ECoG recordings in brain tumor patients. This project provides an interdisciplinary approach to studying important issues of neuronal activation and connectivity, using a multitude of techniques such as MEG, ECoG, and MRI. It also supports translational research with the potential to improve preoperative clinical language mapping procedures.

描述（由申请人提供）： 该项目的科学目标是利用脑磁图 (MEG) 更好地了解参与语音处理的皮质网络。使用全头脑磁图进行语音处理的皮层源应使用新颖的工具进行研究，以重建其位置和时间进程。促进这项工作的关键技术发展包括共同注册和标准化 MEG、ECoG 和结构 MRI 数据的方法。语音处理期间的皮质网络连接也将使用神经源重建进行检查。在可能的情况下，所有分析都将与脑肿瘤患者的 ECoG 记录进行交叉验证。 该项目提供了一种跨学科方法，利用 MEG、ECoG 和 MRI 等多种技术来研究神经元激活和连接的重要问题。它还支持转化研究，有可能改善术前临床语言映射程序。