Behavior Genetics of Temperament and Psychopathology

气质行为遗传学和精神病理学

• 批准号: 6836710
• 负责人: AMBER L SINGH
• 金额: $ 2.52万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836710
• 关键词: adolescence (12-20); anxiety disorders; attention deficit disorder; behavioral /social science research tag; behavioral genetics; child psychology; clinical research; conduct disorder; disease /disorder etiology; gene environment interaction; human subject; major depression; middle childhood (6-11); oppositional defiant disorder; personality; predoctoral investigator; psychopathology; questionnaires; statistics /biometry; twin /multiplet

DESCRIPTION (provided by applicant): There is a large body of literature on the interface of childhood temperament characteristics and psychiatric symptoms. A recent meta-analysis indicates that the temperamental characteristic of emotionality is moderately associated with both internalizing and externalizing disorders. The etiology of these associations, however, are largely unknown. The proposed project will examine the genetic and environmental influences underlying the associations between emotionality and internalizing and externalizing symptoms. Data from the Georgia Twin Registry, a population-based sample of 838 twins age 4 - 18, will be used to address several specific aims. These data wilt allow for behavior genetic analyses of both emotionality and symptomatology as well as analyses of covariation between emotionality and each symptom dimension. Previous studies have not yet elucidated whether the associations between emotionality and internalizing and externalizing disorders are due to common underlying genetic or environmental influences. The proposed study will make a unique contribution to the development psychopathology literature by elucidating the nature of these associations using multivariate behavior genetic model-fitting analyses.

描述（由申请人提供）：有大量关于儿童气质特征和精神症状之间关系的文献。最近的一项荟萃​​分析表明，情绪的气质特征与内化和外化障碍有一定的相关性。然而，这些关联的病因在很大程度上尚不清楚。拟议的项目将研究情绪与内化和外化症状之间关联的遗传和环境影响。佐治亚双胞胎登记处的数据是基于人口的 838 名 4 - 18 岁双胞胎样本，将用于实现几个具体目标。这些数据将允许对情绪和症状进行行为遗传学分析，以及对情绪和每个症状维度之间的协变进行分析。先前的研究尚未阐明情绪与内化和外化障碍之间的关联是否是由于共同的潜在遗传或环境影响所致。拟议的研究将通过使用多变量行为遗传模型拟合分析阐明这些关联的性质，对发展精神病理学文献做出独特的贡献。