Cognition, Tobacco Smoke and Nicotinic Receptor Occupancy

认知、烟草烟雾和烟碱受体占用

• 批准号: 7282677
• 负责人: JULIE K STALEY
• 金额: $ 20.79万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-10 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7282677
• 关键词: Abstinence; Area; Attention; Back; Bolus Infusion; Brain; Cigarette; Cognition; Cognitive; Computer information processing; Cotinine; Equilibrium; Future; Image; Infusion procedures; Learning; Life; Measures; Memory; Motor; Nicotine; Nicotine Inhaler; Nicotinic Agonists; Nicotinic Receptors; Numbers; Oral; Outcome Measure; Parents; Performance; Residual state; Role; Scanning; Sex Characteristics; Short-Term Memory; Smoke; Smoker; Smoking; Speed; Testing; Thalamic structure; Tobacco smoke; Tobacco smoking; Trail Making Test; Venous; Verbal Learning; Work; cigarette smoking; day; deprivation; design; executive function; improved; memory recognition; receptor expression; response; single photon emission computed tomography; uptake

DESCRIPTION (provided by applicant): Cognition, Tobacco Smoke and Nicotinic Receptor Occupancy Tobacco smoking has beneficial effects on cognition. In some cases smoking improves cognitive performance and in others it reverses deficits brought on by smoking deprivation. Many of the cognitive enhancing effects of smoking have been attributed to the pharmacological actions of nicotine on nicotinic acetylcholine receptors (nAChR). Nicotine improves performance on working memory tasks, motor response tests of focused and sustained attention and recognition memory. In addition to nicotine, tobacco smoke includes approximately 4000 additional compounds, of which many are pharmacologically active and may contribute to the effects of smoking on cognition. The cognitive effects of nicotine versus tobacco smoke have not yet been delineated. Moreover it is not clear how the degree of nicotine occupancy of brain nicotinic acetylcholine receptors (nAChR ) is correlated with cognitive performance. In the present study we propose to explore the effects of tobacco smoke, denicotinized tobacco smoke and nicotine on performance on cognitive tasks of attention, learning, memory, speed of information processing and executive functions in smokers while they are actively smoking; after 12 -24 h abstinence; after 7 days abstinence and after smoking a nicotine-containing cigarette; a de-nicotinized cigarette and after using the nicotine inhaler. The relationship between cognitive performance and the number of brain (32-nAChR and the amount of nicotine delivered to cortical and subcortical brain areas will be measured using [123I] 5-IA-85380 and SPECT. These exploratory studies will delineate the role of nicotine versus denicotinized tobacco smoke on cognitive performance in acutely abstinent smokers. In addition they will provide critical information about the interaction of nicotine with p2-nAChR and the relationship to improvements in cognitive performance.

描述（由申请人提供）：认知，烟草烟雾和烟碱受体占用烟草吸烟对认知有益影响。在某些情况下，吸烟会改善认知表现，在其他情况下，它会逆转吸烟剥夺带来的缺陷。吸烟的许多认知增强作用归因于尼古丁对烟碱乙酰胆碱受体（NACHR）的药理作用。尼古丁改善了工作记忆任务的性能，集中注意力和持续关注和识别记忆的运动响应测试。除尼古丁外，烟草烟雾还包括大约4000种其他化合物，其中许多化合物具有药理学活性，可能有助于吸烟对认知的影响。尼古丁与烟草烟雾的认知作用尚未被描述。此外，尚不清楚脑烟碱乙酰胆碱受体（NACHR）的尼古丁占用程度如何与认知性能相关。在本研究中，我们建议探索烟草烟雾，否认烟草烟雾和尼古丁对注意力，学习，记忆，信息处理的速度以及吸烟者在积极吸烟时在吸烟者中的认知任务的效果； 12 -24 h节制后； 7天后，在吸烟后戒酒后；使用尼古丁吸入器后，脱糖型香烟。认知性能与大脑数量之间的关系（32-NACHR和将尼古丁的数量交付给皮质和皮层下脑区域将进行测量[123i] 5-ia-85380和SPECT。这些探索性研究将描述尼古丁与诺丁氏毒素的作用，以使认知能力与纯粹的烟雾相互作用，以使其在纯粹的烟雾中互动，以使其在纯粹的烟雾中互动，以使其对纯粹的烟雾进行互联网效果，使他们对纯粹的烟雾进行了互联网的影响。 P2-NACHR以及与认知表现的改善的关系。