Interdisciplinary Training Program in Cancer Genetics

癌症遗传学跨学科培训计划

• 批准号: 7114262
• 负责人: BRIAN S SCHAFFHAUSEN
• 金额: $ 29.87万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114262
• 关键词: Interdisciplinary; Training; Program; Cancer; Genetics

DESCRIPTION (provided by applicant): This is a renewal application for a training program designed to produce postdoctoral and predoctoral trainees in Cancer Genetics. A faculty of 15 mentors are providing intensive training in c a n cer genetics, with concentrations in viral carcinogenesis, signal transduction, basic mechanisms of gene expression, cell cycle control, and DNA rearrangement. Particular focus is placed on models relevant to breast cancer and leukemia/lymphoma. Since its inception five years ago, our program has grown to include 10 current students and has already produced one Ph.D. To expand the training opportunities available to researchers interested in careers dedicated to the cancer problem, we have developed a postdoctoral component. These two components are well integrated; trainees in both the predoctoral and postdoctoral programs work on research topics directly related to cancer, receive didactic instruction relevant to the cancer problem and are exposed to issues related to cancer as a disease through interactions with New England Medical Center. The postdoctoral program is built on strong research training, but also contains a didactic component focused on cancer genetics, presentation experiences designed to sharpen communication skills, and direct interaction with clinicians treating cancer patients. Career counseling is built into the program. An Executive Committee of the Cancer Genetics Training Program selects postdoctoral trainees based on graduate research productivity, grades and letters of reference. We expect that trainees who have completed our program will be highly competitive for faculty level positions at academic centers or within the biotechnology industry where they will continue to address the cancer problem. Predoctoral students enrolled in the Genetics Graduate Program may apply to enter the Cancer Genetics Program. To encourage application, all Genetics students are required to take Cancer Genetics. Selection into the Cancer Genetics Program is based on successful completion of the first year of the Genetics Graduate Program, a strong interest in cancer, and selection of a Cancer Genetics training laboratory for dissertation research. Predoctoral training includes didactic courses, laboratory rotations, seminars and workshops, but the core of the training is the dissertation research. Upon graduation, we expect our Ph.D. students to be prepared for postdoctoral research in areas relevant to cancer.

描述（由申请人提供）：这是一个续签申请 培训计划旨在生产博士后学员 癌症遗传学。由15位导师组成的教师正在提供深入的培训 C A N CER遗传学，浓度在病毒癌中，信号 转导，基因表达的基本机制，细胞周期控制和DNA 重排。特别关注与乳腺癌相关的模型 和白血病/淋巴瘤。自五年前成立以来，我们的计划已有 成长为包括10名现任学生，并且已经获得了一位博士学位。到 扩大感兴趣的研究人员可用的培训机会 致力于癌症问题的职业，我们已经开发了博士后 成分。这两个组成部分是完善的。两个学员 专业和博士后计划在研究主题上直接相关的研究主题 到癌症，接受与癌症问题有关的教学教学，并且是 通过与新的相互作用，暴露于与癌症作为疾病有关的问题 英格兰医疗中心。 博士后计划建立在强大的研究培训上，也是 包含一个注重癌症遗传学的教学成分，表现 旨在提高沟通技巧和直接互动的经验 与临床医生治疗癌症患者。职业咨询已内置 程序。癌症遗传学培训计划的执行委员会 根据研究生研究的生产力选择博士后学员，成绩 和参考书。我们希望完成我们的学员 课程对于学术的教师职位将具有很高的竞争力 中心或生物技术行业将继续 解决癌症问题。 参加遗传学研究生课程的专业学生可能适用于 输入癌症遗传学计划。为了鼓励应用，所有遗传学 要求学生服用癌症遗传学。选择癌症 遗传学计划基于成功完成的第一年 遗传学研究生计划，对癌症的浓厚兴趣以及选择 癌症遗传学培训实验室的论文研究。主肠道 培训包括教学课程，实验室轮换，研讨会和 讲习班，但培训的核心是论文研究。之上 毕业，我们希望我们的博士学位为博士后准备的学生 与癌症相关的地区的研究。

项目成果

A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization.

Bicaudal D1 是一种新型蛋白酶激活受体 1 相互作用因子，可调节 G 蛋白信号传导和内化。

• DOI: 10.1074/jbc.m110.105403
• 发表时间: 2010
• 期刊: The Journal of biological chemistry
• 作者: Swift,Steven;Xu,Jian;Trivedi,Vishal;Austin,KarynM;Tressel,SarahL;Zhang,Lei;Covic,Lidija;Kuliopulos,Athan
• 通讯作者: Kuliopulos,Athan

Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus.

在 Abelson 鼠白血病病毒的前 B 细胞转化过程中，p19Arf 定位的变化伴随着细胞凋亡危机。

• DOI: 10.1128/jvi.00348-08
• 发表时间: 2008
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Zimmerman,RebekahStackpole;Rosenberg,Naomi
• 通讯作者: Rosenberg,Naomi