Biobehavioral Effects of Yoga During Cancer Treatment

瑜伽在癌症治疗期间的生物行为影响

• 批准号: 7056188
• 负责人: Lorenzo Cohen
• 金额: $ 22.19万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056188
• 关键词: alternative medicine; behavioral /social science research tag; biomechanics; breast neoplasms; clinical research; combination therapy; cortisol; female; human subject; immune response; lung; meditation; psychobiology; psychological aspect of cancer; psychological stressor; quality of life; radiation therapy; respiratory function

DESCRIPTION (provided by applicant): Cancer and its treatment are associated with considerable distress, impaired quality of life, poor mental health, and reduced physical function. This is particularly true for women with breast cancer who receive multimodal treatment over an extended period of time. Many women undergo surgery and chemotherapy, which are often followed by radiotherapy. It is important to develop programs that can help ameliorate the treatment-related morbidity that accumulates over time for women with breast cancer. Furthermore, given the stressful time demands posed by radiotherapy treatment (patients typically receive treatment 5 days per week for 6 weeks) it is crucial that programs be easily incorporated into the treatment schedule. Research suggests that stress-reduction programs tailored to the cancer setting may help patients cope with the acute effects of treatment and improve QOL after treatment. Yoga, an ancient Indian science, incorporates stress-reduction techniques including regulated breathing, visual imagery, meditation, and various gentle stretching postures. Yoga may be particularly useful for women with breast cancer after surgery and while undergoing radiation treatment because of the stress management and relaxation techniques and the gentle stretching that should facilitate recovery. In this feasibility/pilot project, we will pilot-test and examine the feasibility and usefulness of conducting a yoga program with breast cancer patients as an adjuvant to their radiotherapy treatment. Breast cancer patients undergoing radiotherapy treatment will be randomly assigned to a yoga group or an educational support group. Participants in both groups will attend two sessions each week throughout their 6-week radiation therapy treatment schedule. The sessions will be coordinated with the treatment schedule and conducted adjacent to the treatment facility. Measures will be obtained prior to randomization and 1 week and 1 month after the last session. In addition to determining the acceptability and feasibility of the program, this study will also examine the effects of the yoga program on fatigue and sleep disturbances. Secondary indices of adjustment include QOL and mental health. We hypothesize that the yoga program will be feasible and that patients will find the program acceptable and a positive experience. Integrating a yoga program into the treatment regimen for women undergoing radiotherapy will make it relatively easy to participate in the program and we hypothesize that such a program will help facilitate recovery and alleviate the psychological and physical side effects experienced by patients who are currently receiving radiotherapy.

描述（由申请人提供）：癌症及其治疗与相当大的困扰，生活质量受损，精神健康不良和身体机能减少有关。对于长时间接受多模式治疗的乳腺癌女性而言，这尤其如此。许多妇女接受手术和化学疗法，通常进行放疗。重要的是要开发可以帮助改善与治疗相关的发病率的计划，从而使乳腺癌女性随着时间的流逝而积累。此外，鉴于放射治疗所提出的压力时间（通常每周接受5天治疗6周）提出的压力时间，至关重要的是，将程序轻松纳入治疗时间表至关重要。研究表明，针对癌症设置的压力减少计划可以帮助患者应对治疗的急性影响并改善治疗后的QOL。瑜伽是一门古老的印度科学，结合了减少压力的技术，包括受调节的呼吸，视觉图像，冥想和各种柔和的伸展姿势。瑜伽在手术后对乳腺癌女性特别有用，并且由于压力管理和放松技术以及应促进康复的柔和拉伸而接受放射治疗的同时。在这个可行性/试点项目中，我们将进行试点测试并检查与乳腺癌患者进行瑜伽计划的可行性和实用性，作为其放射治疗的辅助。接受放疗治疗的乳腺癌患者将随机分配给瑜伽组或教育支持组。两组的参与者将在他们的6周放射治疗时间表中每周参加两次课程。课程将与治疗时间表协调，并在治疗设施附近进行。将在随机分组之前以及最后一次会议后的1周和1个月获得措施。除了确定该计划的可接受性和可行性外，本研究还将检查瑜伽计划对疲劳和睡眠障碍的影响。调整的次要指标包括QOL和心理健康。我们假设瑜伽计划是可行的，并且患者将发现该计划可以接受和积极的经验。将瑜伽计划整合到接受放射疗法的妇女的治疗方案中，将使参与该计划相对容易，我们假设这样的计划将有助于促进康复并减轻目前正在接受放射治疗的患者所经历的心理和身体副作用。