Yoga for women with breast cancer undergoing radiotherapy

适合接受放射治疗的乳腺癌女性的瑜伽

• 批准号: 8041091
• 负责人: Lorenzo Cohen
• 金额: $ 24.82万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8041091
• 关键词: Acute; Address; Adherence; Adjuvant; Adverse effects; Aftercare; Anxiety; Appointment; Attention; Behavior; Breast Cancer Treatment; Breathing; Cancer Patient; Cessation of life; Cognitive; Combined Modality Therapy; Control Groups; Cost Effectiveness Analysis; Counseling; Diagnosis; Disease Progression; Distress; Emotional; Fatigue; Fright; Health; Health Care Costs; Home environment; Hospitals; Hydrocortisone; Individual; Intervention; Life; Lung; Maintenance; Malignant Neoplasms; Measures; Mediating; Meditation; Mental Depression; Mental Health; Morbidity - disease rate; Movement; Operative Surgical Procedures; Outcome; Participant; Patients; Periodicity; Phase III Clinical Trials; Physical Function; Physical activity; Physiological; Posture; Process; Productivity; Psychological Side Effects; Quality of life; Radiation; Radiation therapy; Randomized; Recovery; Recurrence; Relaxation; Relaxation Techniques; Reporting; Research; Schedule; Science; Skin; Sleep disturbances; Social support; Source; Spirituality; Stress; Stretching; Symptoms; Techniques; Telephone; Time; Trauma; Treatment Efficacy; Treatment Protocols; Woman; Work; Yoga; arm; behavior change; body-mind; cancer therapy; chemotherapy; coping; cost effectiveness; economic outcome; experience; follow-up; group intervention; improved; indexing; intervention effect; malignant breast neoplasm; preference; programs; psychologic; public health relevance; social; social model; standard of care; stress management; stressor; treatment as usual; treatment effect; treatment planning; visual imagery

DESCRIPTION (provided by applicant): Cancer and its treatment are associated with considerable distress, impaired quality of life (QOL), poor mental health, and reduced physical function. This is particularly true for women with breast cancer who receive multimodal treatment over an extended period of time. Many women undergo surgery and chemotherapy, which are often followed by radiotherapy. It is important to develop programs that can help ameliorate the treatment-related morbidity that accumulates over time for women with breast cancer. Furthermore, given the stressful time demands posed by radiotherapy treatment (patients typically receive treatment 5-days per week for 6 weeks) it is crucial that programs be easily incorporated into the treatment schedule. Research suggests that stress-reduction programs tailored to the cancer setting may help patients cope with the acute effects of treatment and improve QOL after treatment. Yoga, an ancient Indian science, incorporates stress-reduction techniques including regulated breathing, visual imagery, meditation, and various gentle stretching postures. Yoga may be particularly useful for women with breast cancer after surgery and while undergoing radiation treatment because of the stress management and relaxation techniques and the gentle stretching that should facilitate recovery. Preliminary studies found yoga is useful for women with breast cancer undergoing radiotherapy. Integrating a yoga program into the treatment regimen of women undergoing radiotherapy for breast cancer makes participation in the program easy and compliance has been high. We will determine the efficacy of implementing a yoga program for patients with breast cancer as an adjuvant to their radiotherapy. Patients with breast cancer who are undergoing radiotherapy will be randomly assigned to one of three groups: a yoga group, a stretching/relaxation group, or a waitlist control group. Participants in the two intervention groups will attend sessions 3 days/week throughout their 6-week radiotherapy schedule. Measures will be obtained prior to randomization, midway through radiotherapy, during the last week of radiotherapy, and 1 and 3, 6 and 12 months after the end of radiotherapy. We will examine indices of QOL, fatigue, sleep disturbances, mental health, cost- effectiveness analysis, work and/or home productivity, and cortisol rhythmicity. We hypothesize that the yoga program will help facilitate recovery and alleviate the physiological and psychological side effects experienced by patients who are currently receiving radiotherapy. PUBLIC HEALTH RELEVANCE: The proposed study will examine efficacy of incorporating a Yoga program alongside radiotherapy for women with breast cancer. If we find that the Yoga program facilitates recovery and alleviates the psychological and physiological side effects experienced by women undergoing radiotherapy, then this type of program can be incorporated into the treatment plan as the standard of care. Future research could examine individual preferences for different types of mind-body or physical activity programs incorporated in the treatment plan to help with recovery.

描述（由申请人提供）： 癌症及其治疗会带来相当大的痛苦、生活质量 (QOL) 受损、心理健康状况不佳和身体机能下降。对于长期接受多模式治疗的乳腺癌女性来说尤其如此。许多女性接受手术和化疗，通常随后进行放疗。制定有助于改善乳腺癌女性随时间累积的治疗相关发病率的计划非常重要。此外，考虑到放射治疗带来的紧张时间要求（患者通常每周接受 5 天治疗，持续 6 周），将计划轻松纳入治疗计划至关重要。研究表明，针对癌症情况量身定制的减压计划可以帮助患者应对治疗的急性影响并改善治疗后的生活质量。瑜伽是一门古老的印度科学，它融合了减压技巧，包括调节呼吸、视觉想象、冥想和各种温和的伸展姿势。瑜伽对于手术后和接受放射治疗的乳腺癌女性特别有用，因为瑜伽可以控制压力、放松技巧以及温和的伸展运动，从而促进康复。初步研究发现瑜伽对于接受放射治疗的乳腺癌女性很有用。将瑜伽项目纳入接受乳腺癌放射治疗的女性的治疗方案中，使参与该项目变得容易，并且依从性很高。我们将确定对乳腺癌患者实施瑜伽计划作为放射治疗的辅助疗法的效果。正在接受放射治疗的乳腺癌患者将被随机分配到三组中的一组：瑜伽组、伸展/放松组或候补对照组。两个干预组的参与者将在为期 6 周的放射治疗计划中每周参加 3 天的会议。测量结果将在随机分组前、放疗中期、放疗最后一周以及放疗结束后 1 个月、3 个月、6 个月和 12 个月内获得。我们将检查生活质量、疲劳、睡眠障碍、心理健康、成本效益分析、工作和/或家庭生产力以及皮质醇节律性等指标。我们假设瑜伽课程将有助于促进康复并减轻目前正在接受放射治疗的患者所经历的生理和心理副作用。 公共卫生相关性： 拟议的研究将检查瑜伽计划与放射治疗结合对乳腺癌女性的疗效。如果我们发现瑜伽项目有助于康复并减轻接受放射治疗的女性所经历的心理和生理副作用，那么此类项目可以纳入治疗计划作为护理标准。未来的研究可以检查个人对治疗计划中纳入的不同类型的身心或身体活动计划的偏好，以帮助康复。