Interhemispheric transfer of grasp control after stroke

中风后抓握控制的半球间转移

• 批准号: 7096766
• 负责人: PREETI RAGHAVAN
• 金额: $ 12.95万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7096766
• 关键词: behavioral /social science research tag; biomechanics; clinical research; electromyography; fingers; functional ability; hand; human subject; interhemispheric transfer; mechanoreceptors; medical rehabilitation related tag; neural information processing; neuromuscular junction; neuropathology; patient oriented research; proprioception /kinesthesia; psychomotor function; psychophysiology; rehabilitation; sensory feedback; stroke; touch; behavioral /social science research tag; biomechanics; clinical research; electromyography; fingers; functional ability; hand; human subject; interhemispheric transfer; mechanoreceptors; medical rehabilitation related tag; neural information processing; neuromuscular junction; neuropathology; patient oriented research; proprioception /kinesthesia; psychomotor function; psychophysiology; rehabilitation; sensory feedback; stroke; touch

DESCRIPTION (provided by applicant): Hemiparesis is the most common motor impairment after stroke that frequently results in persistent hand dysfunction. The long-term goal is to understand the mechanisms underlying the recovery of hand motor function after stroke to provide a scientific rationale for rehabilitation protocols used in clinical practice. The specific hypothesis is that the non-involved hand can assist in the recovery of the involved hand. The PIs base this hypothesis on the observation that prior grasping with the non-involved hand improved anticipatory planning of grasp to object weight with the involved hand in some subjects after stroke. Based on these observations, the focus of this proposal is to investigate the type and nature of information relayed across the hemispheres, by prior manipulation with the non-involved hand, to improve planning and execution of grasp with the involved hand in patients with post-stroke hemiparesis and age-matched controls. The specific aims are to: (1) Investigate whether weight-related information from muscle sensors or tactile information from the fingertips mediates the transfer of anticipatory control to object weight across hands; (2) Examine whether weight-related information for transfer of anticipatory control across hands requires task specific muscular activity; and (3) Determine whether prior manipulation with the non-involved hand improves the temporal and spatial neuromuscular control of grasping with the involved hand. Psychophysical methods using a grip instrument will be used to examine the type of information necessary for planning of grasp, and quantitative electromyography will be used to investigate the contribution of the non-involved hand in improving neuromuscular control of grasp in the involved hand. This project is proposed as part of a career development plan to obtain training in systems neuroscience, motor control, and movement biomechanics, while acquiring skills in psychophysical and electromyographic techniques. The PI is an Instructor in the Department of Rehabilitation Medicine which is strongly committed to supporting research in this field. The Mount Sinai School of Medicine and Teachers College provide a rich environment to enable the PI to become an independent investigator studying the mechanisms of recovery after stroke, and to translate research in motor control into therapeutic protocols for the rehabilitation of voluntary motor functions after brain injury.

描述（由申请人提供）：偏瘫是中风后最常见的运动障碍，经常导致持续的手部功能障碍。长期的目标是了解中风后手运动功能恢复的基础机制，为临床实践中使用的康复方案提供了科学的理由。具体的假设是，非涉及的手可以帮助恢复所涉及的手。 PIS的基础是这一假设，即观察到的观察是，先前用未涉及的手掌握了对掌握的预期掌握的预期计划，从而在中风后某些受试者中与所涉及的手相对体重。基于这些观察结果，该提案的重点是通过事先用无涉及的手操纵整个半球的信息的类型和性质，以改善触诊后半乳液和年龄匹配对照的患者的掌握计划和执行。具体目的是：（1）调查来自肌肉传感器的重量相关信息还是来自指尖的触觉信息是否介导了预期控制的转移到双手对方重量的转移； （2）检查是否需要特定任务的肌肉活动来转移与体重相关的预期控制的信息； （3）确定先前用非涉及手的操纵是否可以改善用所涉及的手对抓握的时间和空间神经肌肉控制。使用握把仪器的心理物理方法将用于检查计划掌握所需的信息类型，并将使用定量肌电图来研究未涉及的手在改善涉及手中抓握的神经肌肉控制方面的贡献。该项目是作为职业发展计划的一部分，旨在获得系统神经科学，运动控制和运动生物力学的培训，同时获得心理物理和肌电图技术的技能。 PI是康复医学系的讲师，强烈致力于支持该领域的研究。西奈山医学学院和教师学院提供了一个丰富的环境，使PI能够成为研究中风后恢复机制的独立研究人员，并将运动控制的研究转化为治疗方案，以恢复脑损伤后自愿运动功能的治疗方案。