PROP SENSITIVITY AND OBESITY AMONG ETHNIC CHILDREN

少数民族儿童对道具的敏感性和肥胖

• 批准号: 7092210
• 负责人: Tom Baranowski
• 金额: $ 44.87万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-08 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7092210
• 关键词: African American; Hispanic Americans; adolescence (12-20); age difference; behavioral genetics; bioenergetics; body composition; caucasian American; chemoreceptors; clinical research; data collection methodology /evaluation; food flavor; gender difference; human subject; longitudinal human study; middle childhood (6-11); nutrient intake activity; nutrition related tag; obesity; racial /ethnic difference; sensory mechanism; social status; socioeconomics; taste

Abstract: Obesity is multifactorial in origin. While energy imbalance is the proximal c# use of obesity, many factors influence energy imbalance. The genetically determined sensitivity to bitter taste (sensitivity to propylthiouracil (PROP)) has been inversely related to obesity among adults and to precursors of obesity (e.g. total energy) among young children. As a possible explanation for these relationships, PROP has also been inversely related to preferences for vegetables with a bitter taste, spicy foods (e g. capsaicin) and dietary fat intake. Thus, PROP sensitivity provides a genetically determined influence on behaviors which may lead to obesity among children. While there is a growing literature on PROP sensitivity in white adults, very little has been published among children or among ethnic minorities. It has not teen established whether this genetically determined trait is expressed at birth and remains constant through life, or if there are developmental influences on its expression. Early work on sensitivity to bitter tastes around the globe suggested large differences in this sensitivity across continents, and thereby ethnic groups. There; are no data, however, on whether the prevalence of PROP sensitivity differs by ethnic group in the US. Thus in one sample this research will assess the prevalence of PROP sensitivity among children in three age arid three ethnic groups, and assess the relationship of PROP sensitivity to adiposity status In a second sample, this research will also assess the relationship of PROP sensitivity to change in BMI over a 7 to 12 year period from 4 or 5 years of age to 12 to 16 years. In addition, both studies will test whether component; dietary intake mediate this relationship after controlling for energy expenditure and other possible confounding factors and whether psychosocial variables mediate the relationship of PROP status to FV intake. Knowing the prevalence of PROP sensitivity by age will specify possible differences in genetic expression by age. Differences in the prevalence by ethnic group could explain ethnic differences in obesity. Understanding how PROP sensitivity relates to obesity and food intake could provide an easily determined stratifying variable to which dietary interventions could be tailored.

摘要：肥胖是多因素的。虽然能量失衡是肥胖的近端C＃使用，但许多因素会影响能量失衡。遗传确定的对苦味味道的敏感性（对丙酸丙酸酯（Prop）的敏感性与成年人的肥胖和肥胖前体（例如，总能量）的肥胖成反比。作为对这些关系的可能解释，道具也与具有苦味的蔬菜，辛辣食物（Eg。辣椒素）和饮食脂肪摄入的蔬菜的偏好成反比。因此，支撑敏感性对行为产生了遗传确定的影响，这可能导致儿童肥胖。尽管关于白人成年人的道具敏感性的文献越来越多，但在儿童或少数民族中，几乎没有发表过。它尚未确定这种遗传确定的特征是否在出生时表达并在生命中保持恒定，还是对其表达产生发育影响。早期对全球苦味品味的敏感性的工作表明，这种敏感性在各大洲的敏感性上存在很大差异，从而使种族群体。那里;但是，没有数据在美国族裔群体的流行率是否有所不同。因此，在一个样本中，这项研究将评估三个年龄的三个族裔儿童的支柱敏感性的普遍性，并评估第二个样本中对肥胖状态的撑起敏感性的关系，这项研究还将评估从4或5岁到12年的7年至12年的7年至12年的BMI改变BMI变化的关系。此外，两项研究都将测试组成部分。饮食摄入控制能量支出和其他可能 混淆因素以及社会心理变量是否介导了道具状况与FV摄入的关系。了解按年龄划分的拟杆敏感性的患病率将指定按年龄划分的遗传表达差异。族裔群体的患病率差异可以解释肥胖的种族差异。 了解道具敏感性与肥胖和食物摄入的关系如何可以提供易于确定的分层变量，从而可以根据哪种饮食干预措施来定制。