MOUSE MUTANT RESOURCE: AIDS

小鼠突变资源：艾滋病

• 批准号: 7391998
• 负责人: MURIEL T DAVISSON
• 金额: $ 30.43万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391998
• 关键词: MOUSE; MUTANT; RESOURCE; AIDS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS DESCRIPTION (provided by applicant): The mission of the Mouse Mutant Resource (MMR) at TJL is to provide a continuing source of new spontaneous mutations for biomedical and biological research. Spontaneous mutations in the mouse are a major source of models for human disorders and have the advantage over genetically engineered mutations in that they are first recognized by producing relevant phenotypes and do not require prior knowledge of the underlying genes. The specific objectives of the MMR program are to: (1) discover new spontaneous mutations in the mouse; (2) characterize the new mutants genetically, phenotypically, and pathologically; (3) establish the new mutations in strains suitable for further analysis; (4) preserve the mutations as frozen embryos or gametes to assure their continued availability and as DNA for future molecular analysis; (5) provide mutant mice and controls to other investigators; and (6) provide information about the mutant mice to others. The new mutations are discovered from among phenotypic deviants appearing in TJL large breeding colonies. They are characterized genetically by determining the mode of inheritance, testing for allelism with known mutations that produce a similar phenotype, and determining the chromosomal location. Each new mutant is characterized phenotypically by observing its growth, viability, fertility, life span, and behavior, and by defining its anatomical, histopathological, and physiological abnormalities. For selected mutants whose phenotype resembles that of an important human disease, the investigators will do further genetic and molecular analysis to identify the mutant gene. The investigators do more in depth analysis on mutants with phenotypes for which a member of the group or a collaborator has specific expertise. The MMR team has expertise in hearing, vision, bone biology, reproduction, and neuropathology. All new mutants with potential for biomedical research will be maintained, preserved as frozen embryos and DNA, and described in the open literature and/or on the MMR and TJL Websites. The overall purpose of the MMR is to make new mutant models available to other investigators for biomedical research.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。关于AIDS描述（申请人提供）：TJL小鼠突变资源（MMR）的使命是为生物医学和生物学研究提供持续的新自发突变的来源。小鼠中的自发突变是人类疾病模型的主要来源，并且比基因工程突变具有优势，因为它们首先通过产生相关表型来识别，并且不需要对基本基因的先验知识。 MMR程序的特定目标是：（1）在鼠标中发现新的自发突变； （2）从遗传，表型和病理上以新的突变体来表征； （3）建立适合进一步分析的菌株中的新突变； （4）将突变保留为冷冻胚胎或配子，以确保其持续可用性，并作为未来分子分析的DNA； （5）向其他研究人员提供突变小鼠和对照； （6）向他人提供有关突变小鼠的信息。新突变是从TJL大繁殖菌落中出现的表型异常中发现的。通过确定遗传模式，通过产生相似表型的已知突变并确定染色体位置来测试等位基因，从而在遗传上表征它们。每个新的突变体的表征都通过观察其生存力，生育力，生命跨度和行为，并定义其解剖学，组织病理学和生理异常。对于某些表型类似于重要人类疾病的突变体，研究人员将进行进一步的遗传和分子分析以鉴定突变基因。研究人员对具有表型的突变体进行了更深入的分析，该表型的组成员或合作者具有特定的专业知识。 MMR团队在听力，视觉，骨骼生物学，繁殖和神经病理学方面具有专业知识。所有具有生物医学研究潜力的新突变体将被维持，保存为冷冻胚胎和DNA，并在开放文献和/或MMR和TJL网站上进行了描述。 MMR的总体目的是使其他研究人员可用于生物医学研究的新突变模型。