Strontium-doped polyphosphate coacervates to aid reparative dentinogenesis in direct pulp capping

掺锶聚磷酸盐凝聚层有助于直接盖髓中的修复性牙本质生成

• 批准号: 2731027
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2731027
• 关键词: Strontium; doped; polyphosphate; coacervates; aid

Dental caries is a major public health problem and reportedly the most common health condition worldwide according to the WHO. When extended past the mineralised protective tissues of the tooth (i.e. enamel and dentine), it causes pain and discomfort by affecting the pulp, which is the soft innermost tissue that harbours nerves and blood vessels along with defensive and reparative functions giving the tooth its vitality. When dental pulp becomes exposed by caries in adult dentition, root canal treatment is frequently indicated. However, a different, less costly and moreconservative approach aimed at protecting this tissue and conserving its vitality is available under the concept of direct pulp capping which briefly consists in applying a compatible material upon the exposed dental pulp. Although many advancements in the field of dental materials have beenachieved during the past two decades, an ideal material for this procedure is not currently available and strontium-doped polyphosphate coacervates constitute a promising - and extremely simple to synthetize - yet unexplored biomaterial for this purpose. The project is aimed at synthesizing and characterising this material and further evaluating the biological response towards it, potentially serving a translational purpose into common dental procedures.

龋齿是一个主要的公共卫生问题，据报道是世界范围内最常见的健康状况。当超过牙齿的矿化保护组织（即搪瓷和牙本质）时，它会通过影响果肉而引起疼痛和不适，这是一种柔软的最内向的组织，可避免神经和血管以及防御和修复功能，使牙齿具有牙齿的活力。当牙髓在成人牙列中被龋齿暴露时，经常表明根管治疗。但是，在直接纸浆封盖的概念下，一种旨在保护该组织并保护其生命力的不同，成本较低和贫穷的方法旨在保护其活力，该概念短暂地包括在裸露的牙纸浆上应用兼容的材料。尽管在过去的二十年中，牙科材料领域的许多进步已经取得了成功，但目前尚无该过程的理想材料，并且跨掺杂的多磷酸盐凝聚力既构成了有希望的 - 非常易于合成 - 但对于此目的而言却没有探索的生物材料。该项目旨在综合和表征这种材料，并进一步评估对其生物学的反应，并有可能将转化目的用于常见的牙科程序。