Exploring surface energies and their impact in pharmaceutical crystals

探索表面能及其对药物晶体的影响

• 批准号: 2726522
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2726522
• 关键词: Exploring; surface; energies; their; impact

Having the ability to link surface structure and energies to changes in surface properties such as adhesion, cohesion and wettability would allow for a more effective early particle risk assessment. This project seeks to measure surface energies (inverse gas chromatography and contact angle measurements) in a number of pharmaceutical crystals (carbamazepine and paracetamol) and compare them to various computer simulations. This analysis would enable a more effective highlight of particle property risks and devise and inform timely strategies for pharmaceutical particle development. This type of prediction is particularly valuable for formulation design and would lead to understanding of agglomeration, segregation and electrostatic charging of powder blends.

能够将表面结构和能量与粘附力、内聚力和润湿性等表面特性的变化联系起来，将有助于更有效地进行早期颗粒风险评估。 该项目旨在测量多种药物晶体（卡马西平和扑热息痛）的表面能（反气相色谱法和接触角测量），并将其与各种计算机模拟进行比较。 该分析将能够更有效地突出颗粒特性风险，并及时制定药物颗粒开发策略并提供信息。这种类型的预测对于配方设计特别有价值，并将有助于理解粉末混合物的团聚、偏析和静电充电。