Neural Substrates of Emotion in Borderline Patients

边缘患者情绪的神经基础

• 批准号: 7034041
• 负责人: ERIN A. HAZLETT
• 金额: $ 38.14万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7034041
• 关键词: aggression; amygdala; behavioral /social science research tag; bioimaging /biomedical imaging; borderline personality disorder; brain mapping; clinical research; emotions; functional magnetic resonance imaging; glucose metabolism; human subject; impulsive behavior; neural information processing; neuroimaging; positron emission tomography; prefrontal lobe /cortex; psychological tests; psychopathology; psychophysiology; schizoid personality; startle reaction

DESCRIPTION (provided by applicant): Borderline personality disorder (BPD) is a persistent and severe mental disorder with high mortality, morbidity and levels of distress. Emotional dysregulation or reactivity to environmental events, particularly events such as separations, frustrations, or losses is considered a defining feature of this disorder. This disorder, has received little investigative scrutiny and the neural correlates of abnormal emotional processing are not understood. Startle eyeblink modification (SEM) methodology provides a non-verbal, quantitative tool for the study of emotional processing. When a brief startle stimulus is presented during an unpleasant stimulus, the amplitude of the startle response is potentiated; a pleasant stimulus occasions a relative inhibition of the startle response; and a neutral stimulus is intermediate. This study uses SEM and functional neuroimaging (event-related fMRI and FDG-PET) to explore the intensity, time course, habituation and functional neuroanatomy of emotional responses in three rigorously screened groups: 26 BPD patients (with no comorbid Axis I disorder or Cluster A or C personality disorders), 26 non-BPD patients (with a diagnosis of schizotypal personality disorder and no comorbid Cluster B or C personality disorders or Axis I disorder) and 26 healthy controls. During both the fMRI scan and FDG-uptake for PET, participants will view an intermixed series of unpleasant (e.g., hate), pleasant (e.g., happy) and neutral (e.g., view) words. SEM amplitude difference scores (e.g., unpleasant-pleasant) measured during simultaneous FDG uptake will provide a measure of the intensity, time course, and habituation of emotional processing of unpleasant stimuli and be correlated with regional glucose metabolism. fMRI BOLD response difference scores in key brain regions will provide measurement of the intensity and time course of brain activation. We focus on three brain regions thought to be involved in emotional processing: amygdala, anterior cingulate, and prefrontal cortex (orbitofrontal and dorsolateral). These regions are part of a brain circuit thought to mediate emotional experience and play a significant role in the expression of BPD symptoms. This proposed combination of a psychophysiological and functional neuroanatomy approach holds the potential to provide much-needed information on normative aspects of emotional processing and insights into the neuroanatomy underlying the emotional dysregulation observed in BPD.

描述（由申请人提供）：边界人格障碍（BPD）是一种持续且严重的精神障碍，死亡率高，发病率和困扰水平。情绪失调或对环境事件的反应性，尤其是诸如分离，挫败感或损失之类的事件被认为是这种疾病的定义特征。这种疾病几乎没有受到调查的审查，并且尚不清楚异常情绪处理的神经相关性。惊吓Ekeyblink修改（SEM）方法论提供了一种非语言，定量的工具，用于研究情绪处理。当在不愉快的刺激中提出短暂的惊吓刺激时，惊吓反应的幅度就会增强。令人愉悦的刺激是对惊吓反应的相对抑制作用；中性刺激是中间的。这项研究使用SEM和功能性神经影像（与事件相关的fMRI和FDG-PET）来探索三个严格筛查组中情绪反应的强度，时间过程，习惯和功能性神经术的术：26个BPD患者：没有合并症或没有合并症的患者（与a或c人群的疾病）（无诊断性疾病）（无诊断）（26个诊断患者），并具有诊断性的特征，群集B或C个性障碍或轴I障碍）和26个健康对照。在宠物的fMRI扫描和FDG摄取过程中，参与者将看到一系列混合的不愉快（例如仇恨），愉快（例如，快乐）和中性（例如，视图）单词。同时FDG摄取期间测得的SEM振幅差异得分（例如，令人不快的）将提供衡量不愉快刺激情绪处理的强度，时间过程和习惯，并与区域葡萄糖代谢相关。关键大脑区域的fMRI BOLD响应差异得分将提供大脑激活的强度和时间过程的测量。我们专注于三个被认为参与情绪处理的大脑区域：杏仁核，前扣带回和前额叶皮层（眶额和背侧）。这些区域是脑电路的一部分，该区域被认为可以介导情感体验并在BPD症状的表达中发挥重要作用。这种心理生理学和功能性神经解剖学方法的组合具有潜力，可以提供有关情绪处理的规范方面以及对BPD中观察到的情绪失调的神经解剖学的洞察力的急需信息。