Adolescent Anabolic Steroids, GABA and Aggression

青少年合成代谢类固醇、GABA 和攻击性

• 批准号: 7091572
• 负责人: JILL M GRIMES
• 金额: $ 2.35万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-22 至 2007-03-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7091572
• 关键词: GABA receptor; adolescence (12-20); aggression; amygdala; androgen analog; autoradiography; behavioral /social science research tag; biological models; gamma aminobutyrate; hamsters; hypothalamus; immature animal; immunocytochemistry; model design /development; neural transmission; neuropharmacology; neuroregulation; neurotransmitter antagonist; predoctoral investigator; receptor expression; steroids; substance abuse related behavior; GABA receptor; adolescence (12-20); aggression; amygdala; androgen analog; autoradiography; behavioral /social science research tag; biological models; gamma aminobutyrate; hamsters; hypothalamus; immature animal; immunocytochemistry; model design /development; neural transmission; neuropharmacology; neuroregulation; neurotransmitter antagonist; predoctoral investigator; receptor expression; steroids; substance abuse related behavior

DESCRIPTION (provided by applicant): The focus of this research proposal is to examine the role of GABA in adolescent anabolic steroid induced aggression. The GABAergic neural system is implicated in the control of aggression yet the role of GABA neurotransmission in this behavior is unclear. Exposure to AAS has been shown to increase aggression in hamsters and it is possible that exposure during adolescence alters the normal development of the GABA system. The GABAergic neural system is of particular interest in this paradigm because it has been shown that steroids directly interact with GABAA receptors in brain. Recent data shows that adolescent AAS exposure results in alterations in GAD65-ir in primary aggression areas in hamster brain and correlates with increased aggression. The goals of the experiments outlined in this proposal are 1) to manipulate adolescent AAS-induced aggression by pharmacologically targeting the GABAA receptor and 2) to examine how adolescent AAS exposure can alter the activity and/or expression of the GABA system to provide a more complete model of the circuitry involved in AAS-induced aggression. These studies will provide a better understanding of GABA's role in the neural and behavioral effects of adolescent steroid abuse.

描述（由申请人提供）： 该研究建议的重点是检查GABA在青少年合成代谢类固醇引起的攻击中的作用。 GABA能神经系统与控制侵略有关，但GABA神经传递在这种行为中的作用尚不清楚。暴露于AAS已显示出增加仓鼠的攻击性，青春期的暴露可能会改变GABA系统的正常发展。 GABA能神经系统在该范式中特别感兴趣，因为已表明类固醇直接与大脑中的GABAA受体相互作用。最近的数据表明，青少年AAS暴露会导致仓鼠大脑初级侵略区域GAD65-IR的改变，并且与攻击性的增加相关。本提案中概述的实验目标是1）通过在药理学上靶向GABAA受体来操纵青少年AAS诱导的攻击，并且2）检查青少年AAS暴露如何改变GABA系统的活性和/或表达，以提供涉及AAS诱导的侵袭的更完整的电路模型。这些研究将更好地了解GABA在青少年类固醇滥用的神经和行为影响中的作用。