Early Onset Schizophrenia; Neuroimaging Studies

早发性精神分裂症；

• 批准号: 7263657
• 负责人: Sanjiv Kumra
• 金额: $ 10.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-10 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7263657
• 关键词: adolescence (12-20); bioimaging /biomedical imaging; brain morphology; child psychology; clinical research; cognition; disease /disorder onset; functional magnetic resonance imaging; human subject; interview; memory; neuroimaging; neuropsychological tests; patient oriented research; psychometrics; psychomotor function; schizophrenia; stimulus /response; visual perception

DESCRIPTION (provided by applicant): This application for a Mentored Patient-Oriented Career Development Award (K23) is from a board-certified child and adolescent psychiatrist. He is proposing a research career development plan that will enable him to investigate late postnatal changes in the brain and their relationship to early-onset schizophrenia (EOS) (onset of psychotic symptoms by age 16) using neuroimaging technology. The applicant has preliminary data (Kumra et al, 2000) demonstrating a pattern of structural brain abnormalities in adolescents with EOS (e.g., subtle reduction in total cerebral volume largely accounted for by a reduction in gray matter, enlarged lateral ventricles) similar to those reported in adult patients with unspecified age at onset of schizophrenia. The applicant proposes to learn how to conduct additional neuroimaging studies examining white matter tract integrity in adolescents with EOS as inferred from diffusion tensor neuroimaging (DTI). DTI is a magnetic resonance imaging technique suited to the study of white matter because it can be used to quantify the magnitude and directionality of tissue water mobility in three dimensions. DTI provides a new method for estimating myelination in vivo. This technique may supply information about delays in brain ontogeny which may contribute to the vulnerability for an early onset of schizophrenia. The training plan will increase the applicant?s knowledge of methodological issues regarding structural imaging, DTI and comprehensive neuropsychological assessment methods. The training goals will be accomplished through the completion of the research plan. The research plan will provide the candidate with an opportunity to independently design, conduct, and complete a neuroimaging study in its entirety under the supervision of a group of experienced mentors. The training experiences in this award will provide the applicant with the necessary skills and experiences to independently undertake neuroimaging studies in the future and effectively compete for grant support.

描述（申请人提供）：此申请的指导 面向患者的职业发展奖（K23）来自董事会认证的孩子 和青少年精神科医生。他正在提出研究职业发展计划 这将使他能够调查大脑产后晚期变化，并 它们与早期精神分裂症（EOS）的关系（精神病发作 症状按年龄16）使用神经影像技术。申请人有 初步数据（Kumra等，2000）证明了结构的模式 EOS青少年的脑异常（例如，总体上的细微降低 大脑体积在很大程度上是通过减少灰质的减少来解释的 外侧心室）类似于成年患者报告的 精神分裂症发作时未指定的年龄。申请人建议了解如何 进行研究的其他神经影像学研究 通过扩散张量推断出具有EOS的青少年的完整性 神经影像学（DTI）。 DTI是一种适合该技术的磁共振成像技术 研究白质，因为它可以用于量化大小和 在三个维度上组织水迁移的方向性。 DTI提供了新的 估计体内髓鞘化的方法。该技术可能会提供 有关大脑个体发育延迟的信息，这可能有助于 精神分裂症早期发作的脆弱性。培训计划将 增加申请人对方法论问题的了解 结构成像，DTI和全面的神经心理学评估 方法。培训目标将通过完成 研究计划。研究计划将为候选人提供机会 独立设计，进行和完成神经影像学研究 在一群经验丰富的导师的监督下整体。培训 该奖项的经验将为申请人提供必要的技能 以及未来独立进行神经影像学研究的经验 并有效竞争赠款支持。

项目成果

Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use.

• DOI: 10.1016/j.jpsychires.2008.12.002
• 发表时间: 2009-01
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Ashtari M;Cervellione K;Cottone J;Ardekani BA;Sevy S;Kumra S
• 通讯作者: Kumra S

Medial temporal structures and memory functions in adolescents with heavy cannabis use.

• DOI: 10.1016/j.jpsychires.2011.01.004
• 发表时间: 2011-08
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Ashtari M;Avants B;Cyckowski L;Cervellione KL;Roofeh D;Cook P;Gee J;Sevy S;Kumra S
• 通讯作者: Kumra S