LONGITUDINAL NEUROIMAGING OF FRONTAL LOBE WHITE MATTER INTEGRITY IN EARLY-ONS

早期额叶白质完整性的纵向神经影像

• 批准号: 7377150
• 负责人: Sanjiv Kumra
• 金额: $ 0.93万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377150
• 关键词: LONGITUDINAL; NEUROIMAGING; FRONTAL; LOBE; WHITE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aims are to investigate white matter (WM) tract integrity in children and adolescents with early-onset schizophrenia (EOS; onset of psychosis prior to age 18) as inferred from diffusion tensor imaging (DTI) using a longitudinal study design. Preliminary data from our initial study using cross-sectional methodologies have helped to strengthen our hypotheses that, in EOS, abnormalities in the maturation of neural circuits in prefrontal areas, in cortico-cortical projections, and in cortical projections to lower regions produce detectable anatomic pathology in white matter that results in inappropriate or maladaptive information processing (Hyman, 2000). Demonstration of WM microstructure abnormalities in children and adolescents with EOS using a longitudinal design will reveal an aspect of brain structure development and physiology that, to our knowledge, has not yet been explored. In this application we propose to acquire a second magnetic resonance imaging scan from 30 patients with EOS (ages 10 to 22) and 30 demographically matched controls (ages 10 to 22) that have previously participated in the baseline portion of this study up to 3 years after their initial scan. Specific aims: 1) To quantify the fractional anisotropy (FA) of white matter fibers in vivo using diffusion tensor imaging (DTI) in adolescents with early-onset schizophrenia and normal controls at two time-points. 2) To determine the developmental trajectory of white matter changes over time in both patients with EOS and controls and to explore how those trajectories differ between groups.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。主要目的是调查患有早发性精神分裂症（EOS；18 岁之前精神病发作）的儿童和青少年的白质 (WM) 束完整性，这是使用纵向研究设计从弥散张量成像 (DTI) 推断的。我们使用横断面方法进行的初步研究的初步数据有助于加强我们的假设，即在 EOS 中，前额叶区域、皮质-皮质投射以及皮质投射到下部区域的神经回路成熟异常会产生可检测的解剖病理学导致不适当或适应不良的信息处理的白质（Hyman，2000）。使用纵向设计证明患有 EOS 的儿童和青少年的 WM 微观结构异常将揭示大脑结构发育和生理学的一个方面，据我们所知，这一方面尚未被探索。在此应用中，我们建议对 30 名 EOS 患者（年龄 10 至 22 岁）和 30 名人口统计学匹配的对照者（年龄 10 至 22 岁）进行第二次磁共振成像扫描，这些对照者之前曾参与本研究的基线部分长达 3 年初次扫描后。具体目标：1) 使用弥散张量成像 (DTI) 量化早发精神分裂症青少年和正常对照青少年在两个时间点的体内白质纤维分数各向异性 (FA)。 2) 确定 EOS 患者和对照组白质随时间变化的发育轨迹，并探讨这些轨迹在各组之间有何不同。