Percutaneous Devices Permitting Skin Cell Attachment-Inhibiting Biofilm Formation

允许皮肤细胞附着抑制生物膜形成的经皮装置

• 批准号: 7192310
• 负责人: JOHN Everett OLERUD
• 金额: $ 12.8万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7192310
• 关键词: Percutaneous; Devices; Permitting; Skin; Cell

DESCRIPTION (provided by applicant): The goal of this research is to enhance the fundamental knowledge and research skills of an excellent physician in dermatology training who is interested in a research career. This project takes advantage of the trainee's previous educational experience and incorporates him into an interdisciplinary research team participating in a NIBIB-funded R01, including skin biologists, researchers from two NSF Engineering Research Centers, one with expertise in advanced biomaterials, the other with expertise in the study of biofilm, as well as an industrial partner that develops and markets percutaneous devices for intravascular access. Percutaneous devices play an essential role in patient care; they are used for such diverse functions as dialysis, chemotherapy, attachments for prosthetic limbs and percutaneous sensors (glucose). However, the risks of infections associated with penetrating the skin are not inconsequential. Central venous catheters alone are associated with an estimated 80,000 to 250,000 blood stream infections annually, with an associated mortality of 12%-25% for each infection and a cost of >$28,000 per episode. The goal of the grant is to create an interface that promotes epidermal and dermal cell integration with the surface of percutaneous medical devices while minimizing biofilm formation. We believe that healing the cutaneous wound with cellular integration into percutaneous medical devices will provide a seal preventing bacterial attachment and subsequent biofilm formation. The trainee will carry out the Specific Aim to evaluate bacterial attachment and biofilm formation as a function of skin/biomaterial integration. The training will contribute significantly to his research career development, and information gained from this work will help prevent the most common cause of serious complications associated with these devices.

描述（由申请人提供）： 本研究的目的是提高对研究职业感兴趣的皮肤科培训优秀医生的基础知识和研究技能。该项目利用学员之前的教育经验，将其纳入一个参与 NIBIB 资助的 R01 的跨学科研究团队，其中包括皮肤生物学家、来自两个 NSF 工程研究中心的研究人员，一个在先进生物材料方面拥有专业知识，另一个在生物膜研究，以及开发和销售用于血管内通路的经皮设备的工业合作伙伴。经皮装置在患者护理中发挥着重要作用；它们具有多种功能，如透析、化疗、假肢附件和经皮传感器（葡萄糖）。然而，与穿透皮肤相关的感染风险并非无关紧要。据估计，每年仅中心静脉导管就与 80,000 至 250,000 起血流感染相关，每次感染的相关死亡率为 12%-25%，每次感染的费用超过 28,000 美元。该拨款的目标是创建一个界面，促进表皮和真皮细胞与经皮医疗设备表面的整合，同时最大限度地减少生物膜的形成。我们相信，通过细胞整合到经皮医疗器械中来治愈皮肤伤口将提供密封，防止细菌附着和随后的生物膜形成。学员将执行特定目标来评估细菌附着和生物膜形成作为皮肤/生物材料整合的功能。该培训将对他的研究职业发展做出重大贡献，从这项工作中获得的信息将有助于预防与这些设备相关的严重并发症的最常见原因。