Core--Health Outcomes

核心——健康成果

• 批准号: 6939109
• 负责人: Peter Howard Stone
• 金额: $ 31.51万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6939109
• 关键词: air pollution; biomedical facility; disease /disorder proneness /risk; outcomes research

A primary goal of this Program Project renewal is to understand the relation of ambient particle pollution to cardiovascular physiologic, hematologic and biochemical outcomes reflecting potential mechanisms that might explain the known associations of pollution with cardiac morbidity and mortality. To accomplish these objectives, we will establish a Health Outcomes Core with an Ambulatory ECG Component, a new Vascular/Inflammatory Component, and a third component for the secure tracking and storage of blood specimens. The overall objectives of The Health Outcomes Core will be: 1. To provide centralized, standardized, comparable measurement of physiologic, hematologic, and biochemical health outcomes including: a. Analysis of all ambulatory ECG (AECG) data generated by subprojects for heart rate variability (measure of autonomic function), standard clinical ECG outcomes, and project-specific cardiac ECG endpoints which have proved to be of interest based on recent investigations of the effects of air pollution in both animals and humans (e.g., tachyarrhythmias, ST-segment changes) b. Vascular outcomes (brachial artery diameter, endothelium-dependent flow-mediated arterial dilation endothelium non-dependent vasodilation, pulse-wave analysis) for Type 2 diabetic and coronary artery disease subjects c. Hematologic and biochemical measures of cardiovascular risk and diabetes control for Type 2 diabetic and coronary artery disease subjects d. Hematologic and biochemical markers of systemic inflammation and endothelial activation for subprojects 2. To provide centralized, secure storage and tracking of blood specimens. 3. To be a resource of expertise in cardiology, vascular disease, and diabetes for subprojects.

该计划项目更新的主要目标是了解环境颗粒污染与心血管生理，血液学和生化结果的关系，这反映了潜在的机制，这些机制可能解释了已知的污染与心脏发病率和死亡率的关联。为了实现这些目标，我们将建立具有门诊心电图组件，新的血管/炎症成分以及第三个组件的健康成果核心，以固定血液标本的安全跟踪和存储。健康结果的总体目标将是： 1。提供对生理，血液学和生化健康结果的集中，标准化，可比的测量 一个。对心率下生成的所有门诊数据（AECG）数据的分析 可变性（自主功能的度量），标准临床心电图结果和特定于项目的 基于对动物和人类空气污染的影响的最新研究，事实证明，心电图端点很感兴趣（例如，心律失常，ST段变化） b。血管结局（肱动脉直径，内皮依赖性流动介导的动脉扩张内皮无依赖性血管舒张，脉冲波分析），用于2型糖尿病和冠状动脉疾病。 c。 2型糖尿病和冠状动脉疾病受试者的心血管风险和糖尿病控制的血液学和生化措施 d。系统炎症的血液学和生化标志物和下皮激活 2。提供集中的，安全的存储和跟踪血样。 3。成为心脏病学，血管疾病和糖尿病的专业知识的资源。