CORE--RESPIRATORY EFFECTS

核心——呼吸效应

• 批准号: 6667473
• 负责人: JOHN M PETERS
• 金额: $ 11.79万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6667473
• 关键词: air pollution; asthma; biomedical facility; clinical research; disease /disorder proneness /risk; environmental health; human subject; pollution related respiratory disorder; respiratory disorder epidemiology; statistics /biometry

The two objectives of this Core are: 1) to understand how indoor and outdoor air pollution contributes to human respiratory diseases (including asthma), and 2) how host factors (i.e., sensitivity) influence the pathogenic process. This Core studies large populations epidemiologically and smaller groups in experimental chamber studies. Thus, it is involved in looking at both acute and chronic respiratory effects in multiple studies. This Core works closely with the Exposure Assessment (EA) Core and the Cores involved in study design and biostatistics. There are several ongoing research projects in which this Core works: There is a major longitudinal population study of chronic respiratory effects of air pollution in children in different communities in Southern California (supported by CARB). An additional grant (supported by EPA, NIEHS, NHLBI) is now evaluating dietary factors and some genetic polymorphisms. There are two ongoing experimental chamber studies of cardio-pulmonary responses of health and asthmatic subjects to particulates using an ambient particle concentrator (supported by EPA and HEI).

该核心的两个目标是：1）了解如何 室内和室外空气污染有助于人类呼吸系统疾病 （包括哮喘）和2）宿主因素（即灵敏度）如何影响 致病过程。该核心在流行病学和 实验室研究中的较小组。因此，它参与了 在多项研究中查看急性和慢性呼吸效应。 该核心与暴露评估（EA）核心和核心紧密合作 参与研究设计和生物统计学。有几个正在进行的 该核心工作的研究项目：有一个主要的纵向 空气污染对儿童慢性呼吸作用的人口研究 在南加州的不同社区（在Carb的支持下）。一个 额外的赠款（由EPA，NIEHS，NHLBI支持）现在正在评估饮食 因素和一些遗传多态性。有两个正在进行的实验 室内研究健康和哮喘受试者的心肺反应 使用环境颗粒浓缩器（由EPA支撑， 嘿）。