AIR POLLUTION AND CARDIAC VULNERABILITY

空气污染和心脏脆弱性

• 批准号: 7366543
• 负责人: Peter Howard Stone
• 金额: $ 0.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7366543
• 关键词: AIR; POLLUTION; CARDIAC; VULNERABILITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This collaborative project is being conducted with investigators from the Program Project NIH/NIEHS P01 ES09825, Effects of ambient particles on human cardiac vulnerability. The goal of this grant is to identify mechanisms whereby effects of exposure to ambient air pollutants could result in cardiovascular events. The aims are: 1) characterize the physiologic state of at-risk groups; 2) monitor exposure in sufficient detail to characterize and quantify the putative environmental agents; 3) make detailed and appropriately sustained measures of cardiac function that are relevant to assessing the autonomic response of the heart; and 4) correlate these potential findings with those found in animals exposed to concentrated air particles. PhysioNet investigators are helping to analyze cardiac interbeat interval time series using new methods developed at the Resource to test the hypothesis that increasing levels of air pollution may reduce cardiac vagal tone and decrease the complexity of heart rate regulation, thereby increasing risk of adverse cardiovascular events.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该协作项目是由计划项目NIH/NIEHS P01 ES09825的调查人员进行的，环境颗粒对人类心脏脆弱性的影响。该赠款的目的是确定机制，从而导致环境空气污染物的影响可能导致心血管事件。目的是：1）表征高危人群的生理状态； 2）足够详细的监测暴露以表征和量化推定的环境药物； 3）对与评估心脏的自主反应有关的心脏功能进行详细且适当的心脏功能衡量； 4）将这些潜在发现与暴露于浓缩空气颗粒的动物中发现的结果相关联。 Physionet研究人员正在使用资源上开发的新方法来帮助分析心脏间间隔时间序列，以检验以下假设，即增加空气污染水平可以降低心脏迷走神经张力并降低心率调节的复杂性，从而增加心血管不良事件的风险。