IMPROVEMENT OF THE MU MEDICAL SCHOOL VIVARIUM

MU 医学院动物饲养室的改进

• 批准号: 6769802
• 负责人: LONNY W DIXON
• 金额: $ 63.57万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2007-03-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6769802
• 关键词: Amphibia; animal care; animal colony; biomedical facility; building /facility design /renovation; laboratory mouse; swine

DESCRIPTION (provided by applicant): The long-term goal of the animal resource program of the University of Missouri-Columbia (MU) is to provide an animal resource infrastructure to support and expand the capacity and sophistication of animal-related biomedical research. MU is a land grant university with the unique distinction of having a College of Veterinary Medicine, a School of Medicine, a Division of Biological Sciences, and a College of Agriculture on one campus. In the past five years, extramural research awards to MU have increased 72%, from $73.2 million in FY1998 to $126.1 million in FY2002. Many of these projects involve animal-related research. The animal resource infrastructure at MU is aged but functional. Facilities are operating at maximum capacity and are in need of upgrading to meet the degree of sophistication required in biomedical research today, to assure regulatory compliance with the Animal Welfare Act and the Public Health Service Policy on Humane Care and Use of Laboratory Animals, and to maintain AAALAC accreditation. MU has developed an overall plan to expand and upgrade animal facilities and programs. This request for improvement is part of that plan. This proposal addresses space, regulatory and safety issues within the School of Medicine's animal facility located in the Medical Sciences Building via three aims: 1) Expand the rodent barrier capacity 46% (from 1518 to 2210 net square feet) to meet the needs for housing transgenic and knockout mice; 2) Provide a safer work environment in the autoclave area by renovating the clean side of the cage wash facility to include the autoclave preparation area in order to eliminate a cramped, dangerous preparation area and adding an autoclave for cages entering the barrier; 3) Provide reliable environmental conditions in 12 animal rooms by replacing two HVAC units.

描述（由申请人提供）： 密苏里州哥伦比亚大学（MU）动物资源计划的长期目标是提供动物资源基础设施，以支持和扩大与动物相关的生物医学研究的能力和复杂性。 MU是一所土地格兰特大学，其独特的区别是拥有一所兽医学院，医学院，生物科学系和一个校园的农业学院。在过去的五年中，MU的校外研究奖已从1998财年的7320万美元增加到2002财年的1.261亿美元。这些项目中有许多涉及与动物有关的研究。 MU的动物资源基础设施已老化，但功能正常。设施以最大的身份运行，需要升级以满足当今生物医学研究所需的复杂程度，以确保监管性遵守《动物福利法》以及有关人道护理和实验动物的公共卫生服务政策，并维持AAALAC认证。 MU制定了一项总体计划，以扩展和升级动物设施和计划。此改进请求是该计划的一部分。 该提案通过三个目标解决了医学科学大楼中医学院动物设施内的空间，监管和安全问题：1）扩大啮齿动物屏障容量46％​​（从1518净到2210净平方），以满足住房转基因和敲除小鼠的需求； 2）通过翻新笼子清洗设施的清洁侧，包括高压釜准备区，以消除狭窄，危险的准备区，并为进入障碍物的笼子中添加高压灭菌器； 3）通过更换两个HVAC单元，在12个动物房中提供可靠的环境条件。