A UNIVERSITY RESOURCE IN LABORATORY ANIMAL MEDICINE

实验动物医学方面的大学资源

• 批准号: 3103258
• 负责人: DANIEL H RINGLER
• 金额: $ 32.48万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-09-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103258
• 关键词: Amphibia; Cercopithecidae; Macaca; Macaca mulatta; Pasteurella multocida; Pongidae; animal care; animal colony; animal food; bacterial vaccines; blood coagulation disorders; diagnostic tests; disease /disorder model; dogs; encephalitis; gastrointestinal disorder; health science research; iatrogenic disease; immunization; immunogenetics; immunoregulation; laboratory mouse; laboratory rabbit; microorganism immunology; model design /development; nervous system infection; parasitic diseases; surgery; university; veterinary medicine

We seek renewal of the animal resource laboratory in the Unit for Laboratory Animal Medicine (ULAM) at the University of Michigan (UM). The long term objectives are to protect and enhance UM animal research programs, foster the humane treatment of laboratory animals through excellent professional care, and contribute new knowledge to comparative medicine. The specific aims are: l) to operate a diagnostic laboratory for protecting animal health, including development of new or improved laboratory tests to aid disease diagnosis. The fibrin split products assay, for application to blood coagulation disorders in primates, is one such test to be investigated; 2) to conduct research on diseases that are identified by the diagnostic laboratory and that are deemed to merit further clinical or experimental study. Lower bowel disease and catheter-related infections in primates are examples of spontaneously arising and iatrogenic diseases to be investigated; 3) to continue research on the immunobiology of rabbit pasteurellosis. The development and evaluation of a component vaccine is to be pursued; 4) to develop animal models relevant to human diseases and to problems of human biology such as aging. Projects in this area are development of an adult mouse model of herpes virus encephalitis and study of the possible relationship of age- and strain-associated dysplasia of mouse maxillary incisor teeth to molar periodontitis; 5) to promote research training in laboratory animal and comparative medicine. This would be accomplished through participation in the ARB summer trainee program and by facilitating resident participation in ongoing research. The methods to be used are those of clinical medicine, clinical and anatomic pathology, immunology, immunogenetics and other relevant disciplines.

我们寻求单位中动物资源实验室的续订 密歇根大学（UM）的实验室动物医学（ULAM）。 这 长期目标是保护和增强UM动物研究 程序，通过 优秀的专业护理，并为比较贡献新知识 药品。 具体目的是：l）操作诊断实验室 用于保护动物健康，包括开发新的或改进的 实验室测试以帮助疾病诊断。 纤维蛋白拆分产品 分析，用于在灵长类动物中应用血液凝血疾病，是一种 这样的测试要进行调查； 2）进行有关疾病的研究 由诊断实验室确定，被认为是值得的 进一步的临床或实验研究。 降低肠病和 灵长类动物中与导管相关的感染是自发的例子 引起的和医源性疾病要研究； 3）继续研究 关于兔巴氏病的免疫生物学。 发展和 要评估组件疫苗； 4）发展动物 与人类疾病和人类生物学问题有关的模型，例如 老化。 该领域的项目是成年鼠标模型的开发 疱疹病毒脑炎和研究年龄的可能关系 小鼠上颌切牙牙齿与摩尔的小鼠上颌切牙牙齿的发育不良 牙周炎； 5）促进实验室动物的研究培训和 比较医学。 这将通过参加 ARB夏季学员计划，并通过促进居民参与 在正在进行的研究中。 要使用的方法是临床的方法 医学，临床和解剖病理学，免疫学，免疫遗传学以及 其他相关学科。