Expansion of Rodent Biocontainment at the University of Missouri

密苏里大学啮齿动物生物防护设施的扩建

• 批准号: 7628256
• 负责人: LONNY W DIXON
• 金额: $ 50万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2011-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7628256
• 关键词: Animals; Congenital Abnormality; Disease; Equipment; Funding; Housing; Human; Hydrocephalus; Immunology; Impetigo; Infectious Agent; Infectious Diseases Research; Laboratories; Listeria monocytogenes; Lymphocytic choriomeningitis virus; Microbiology; Missouri; Molecular; Pharyngeal structure; Research; Rodent; Schedule; Spontaneous abortion; Streptococcus pyogenes; Toxic Shock Syndrome; Universities; Veterinary Medicine; Xenograft procedure; college; foodborne illness; medical schools; pathogen; programs; public health relevance; square foot

DESCRIPTION (provided by applicant): This project requests $500,000 to increase rodent biocontainment housing capacity at the University of Missouri-Columbia. Expanding infectious disease research programs in the Departments of Veterinary Pathobiology, College of Veterinary Medicine, and Molecular Microbiology and Immunology, School of Medicine, have created a critical need for additional rodent biocontainment housing. Also, the Regional Biocontainment Laboratory (RBL) on campus is scheduled to open this year; more Animal Biosafety Level 2 (ABSL-2) space will be needed to support the ABSL-3 research conducted in the RBL. At present there is only one rodent biocontainment suite available, located in the College of Veterinary Medicine. This project requests funds to renovate existing vivarium space and to purchase and install equipment which will expand biocontainment housing capacity for rodents from 250 cages in 160 net square feet to a total of 991 cages (~400% increase) in 742 net square feet (464% increase). The space renovated by this application will be used to house rodents experimentally infected with either rodent pathogens or potential human pathogens or rodents receiving xenografts, at the ABSL-2 level. PUBLIC HEALTH RELEVANCE (provided by applicant): Biocontainment space is needed to safely study infectious organisms such as Streptococcus Group A, lymphocytic choriomeningitis virus, and Listeria monocytogenes, all of which can infect humans, causing such diseases as strep throat, impetigo, and streptococcal toxic shock syndrome; miscarriage, hydrocephalus and other birth defects; and food-borne illness.

描述（由申请人提供）：该项目要求$ 500,000，以提高密苏里州哥伦比亚大学的啮齿动物生物自然风化住房能力。扩大兽医病理学，兽医学院以及分子微生物学和免疫学学院的传染病研究计划，医学学院对额外的啮齿动物生物自然保护住房产生了迫切需求。此外，校园的区域生物疗养实验室（RBL）计划于今年开放。需要更多动物生物安全2级（ABSL-2）空间来支持RBL中进行的ABSL-3研究。目前，只有一个位于兽医学院的啮齿动物生物内在套件。该项目要求资金翻新现有的Vivarium空间，并购买和安装设备，以扩大啮齿动物的生物自然保护住房能力，从160净平方英尺的250个笼子到742净平方英尺的总计991个笼子（增加了400％）（增加464％）。该应用翻新的空间将用于容纳在ABSL-2水平下经过啮齿动物病原体或潜在的人类病原体或接收异种移植物的啮齿动物感染的啮齿动物。 公共卫生相关性（由申请人提供）：需要生物内部培养空间来安全地研究感染性有机体，例如链球菌A组，淋巴细胞性绒毛膜炎病毒病毒和单核细胞增生李斯特菌，所有这些都可以感染人类，从而引起人类的疾病，诸如陷入困境的喉咙，Impetigigo，impepigo sock shock shock scempoccalsycocacalsycoccalsycoccalsynecocalsycocacal consyntrorys comnycoccal consyndrome conyntrome conyntrome conyntrome conyncoccal consyndrome;流产，脑积水和其他先天缺陷；和食源性疾病。