HIV Prevention Partnership in Russian Alcohol Treatment

俄罗斯酒精治疗中的艾滋病毒预防伙伴关系

• 批准号: 6945926
• 负责人: JEFFREY H. SAMET
• 金额: $ 35.37万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6945926
• 关键词: AIDS education /prevention; Commonwealth of Independent States; United States; alcoholism /alcohol abuse; alcoholism /alcohol abuse therapy; behavioral /social science research tag; clinical research; data management; drug abuse; high risk behavior /lifestyle; human subject; international cooperation; sex behavior; statistics /biometry; training

DESCRIPTION (provided by applicant): Russia's per capita alcohol consumption is one of the highest of any country. Since 1996, Russia has witnessed a dramatic increase in HIV-infected citizens. Alcohol use is known to increase HIV risk behaviors in general and in drug users in particular. The rapid spread of HIV infection among drug users and the early appearance of HIV in alcohol dependent individuals in Russia raise concern for the spread of HIV among the sizable Russian alcohol-dependent population. While Regional Narcology Hospitals play a central role in Russia's efforts to address alcohol and drug dependence, these treatment centers have not aggressively addressed the current Russian HIV epidemic. The objective of this proposal, Russian-Partnership to Reduce the Epidemic via Engagement in Narcology Treatment (Russian PREVENT) is to expand on an existing international research collaboration to develop and test the feasibility of adapting and implementing an efficacious US HIV prevention intervention, RESPECT, in a Russian substance abuse treatment center. In this study, American researchers will mentor, train, and collaborate with Russian researchers in the areas of data management, biostatistical methods, HIV prevention interventions, and study implementation in order to lay the groundwork for future testing of the efficacy of a culturally adapted HIV prevention intervention. The study will randomize 180 alcohol and drug dependent patients in substance abuse treatment to one of two adapted interventions, assessing at baseline and 6-months HIV risk behaviors and substance use. Data will be collected, managed, and analyzed by Russian researchers under the tutelage of American collaborators. We hypothesize that data from the pilot trial will indicate that Russian subjects with primary diagnoses of alcohol dependence will have greater risk behaviors than those with primary diagnoses of drug dependence. Further, we anticipate that alcohol use in Russians with primary diagnoses of drug dependence will be common and associated with increased high-risk and drug use behaviors. This investigation will allow the adaptation of an HIV prevention intervention to a Russian setting. It will provide data to further define alcohol use and HIV risk behaviors in the narcology hospital population, more clearly identifying the optimal population for a Russian HIV prevention intervention study. Many will be HIV infected. Thus, the successful implementation of this study will provide a critical foundation for future prevention efforts to address the explosion of HIV infection in Russia.

描述（由申请人提供）：俄罗斯的人均酒精消费量是所有国家中最高的之一。自1996年以来，俄罗斯艾滋病病毒感染者人数急剧增加。众所周知，饮酒会增加一般人尤其是吸毒者的艾滋病毒风险行为。艾滋病毒感染在俄罗斯吸毒者中的迅速传播以及艾滋病毒在俄罗斯酒精依赖者中的早期出现，引起了人们对艾滋病毒在俄罗斯大量酒精依赖人群中传播的担忧。虽然地区麻醉科医院在俄罗斯解决酒精和药物依赖问题方面发挥着核心作用，但这些治疗中心并未积极解决俄罗斯当前的艾滋病毒流行问题。该提案“通过参与麻醉学治疗减少流行病的俄罗斯伙伴关系”（俄语 PREVENT）的目的是扩大现有的国际研究合作，以开发和测试调整和实施有效的美国艾滋病毒预防干预措施 RESPECT、在俄罗斯药物滥用治疗中心。在这项研究中，美国研究人员将在数据管理、生物统计方法、艾滋病毒预防干预和研究实施等领域与俄罗斯研究人员进行指导、培训和合作，以便为未来测试适应文化的艾滋病毒的功效奠定基础。预防干预。该研究将 180 名接受药物滥用治疗的酒精和药物依赖患者随机分为两种干预措施之一，评估基线和 6 个月的 HIV 风险行为和药物使用。数据将由俄罗斯研究人员在美国合作者的指导下收集、管理和分析。我们假设试点试验的数据表明，初步诊断为酒精依赖的俄罗斯受试者比初步诊断为药物依赖的受试者有更大的危险行为。此外，我们预计，在初步诊断为药物依赖的俄罗斯人中，饮酒将很常见，并且与高风险和药物使用行为的增加有关。这项调查将使艾滋病毒预防干预措施适应俄罗斯的环境。它将提供数据来进一步定义麻醉科医院人群中的饮酒和艾滋病毒危险行为，更清楚地确定俄罗斯艾滋病毒预防干预研究的最佳人群。许多人将感染艾滋病毒。因此，这项研究的成功实施将为未来解决俄罗斯艾滋病毒感染激增的预防工作奠定重要基础。

项目成果

Mitigating risky sexual behaviors among Russian narcology hospital patients: the PREVENT (Partnership to Reduce the Epidemic Via Engagement in Narcology Treatment) randomized controlled trial.

减少俄罗斯麻醉科医院患者的危险性行为：预防（通过参与麻醉科治疗减少流行病的伙伴关系）随机对照试验。

• DOI: 10.1111/j.1360-0443.2008.02251.x
• 发表时间: 2008
• 期刊: Addiction (Abingdon, England)
• 作者: Samet,JeffreyH;Krupitsky,EvgenyM;Cheng,DebbieM;Raj,Anita;Egorova,ValentinaY;Levenson,Suzette;Meli,Seville;Bridden,Carly;Verbitskaya,ElenaV;Kamb,MaryL;Zvartau,EdwinE
• 通讯作者: Zvartau,EdwinE

Binge drinking and unsafe sex: a study of narcology hospital patients from St. Petersburg, Russia.

酗酒和不安全性行为：对俄罗斯圣彼得堡麻醉科医院患者的研究。

• DOI: 10.1080/08897070903040923
• 发表时间: 2009
• 期刊: Substance abuse
• 影响因子: 3.5
• 作者: Raj,A;Cheng,DM;Krupitsky,EM;Levenson,S;Egorova,VY;Meli,S;Zvartau,EE;Samet,JH
• 通讯作者: Samet,JH

Correlates of any condom use among Russian narcology patients reporting recent unprotected sex.

报告近期无保护性行为的俄罗斯麻醉科患者中任何安全套使用的相关性。

• DOI: 10.1007/s10461-008-9383-3
• 发表时间: 2009
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Raj,Anita;Cheng,DM;Krupitsky,EM;Coleman,S;Bridden,C;Samet,JH
• 通讯作者: Samet,JH