HIV PREVENTION TRIAL UNIT (HPTU)

HIV 预防试验中心 (HPTU)

• 批准号: 7288444
• 负责人: Irving F. Hoffman
• 金额: $ 30万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7288444
• 关键词: AIDS; AIDS education /prevention; AIDS therapy; Commonwealth of Independent States; HIV infections; United States; antiAIDS agent; behavior therapy; behavioral /social science research tag; clinical research; clinical trials; cooperative study; human immunodeficiency virus 1; human subject; human therapy evaluation; medical outreach /case finding; patient oriented research

DESCRIPTION (adapted from applicant's abstract): This application proposes formation of a four-institution consortium, the Eastern Prevention Trials Unit (EPTU) consisting of Yale University School of Public Health (New Haven, CT), State University of New York/Downstate Medical Center (SUNY-DMC) (Brooklyn, NY), the Biomedical Center on AIDS/St. Petersburg State University (SPSU) (St. Petersburg, Russia) and the Center for AIDS Intervention Research (CAIR) at the Medical College of Wisconsin (MCW) (Milwaukee, WI). The investigators propose to enroll into HPTN protocols suitable individuals residing in Connecticut, Brooklyn and St. Petersburg, Russia. MCW will contribute expertise in community-based behavioral intervention studies to the EPTU, particularly in Russia. All four institutions have overlapping geographical and research interests in HIV prevention in the eastern US (ongoing joint studies) and Eastern Europe (AIDS International Training and Research Programs in Russia [Yale/MCW/SPSU] and Eastern Europe [SUNY-DMC]). The EPTU could contribute to the HPTN by: (1) identifying effective prevention strategies; and (2) facilitating their evaluation through the Unit's large international population capacity (population base of 6 million in Connecticut and Brooklyn and 6 million in St. Petersburg). Large segments of this population base have high HIV incidence rates driven by political, economic, social, and demographic instability. The application attributes four significant strengths to the proposed consortium. First, it could provide access to populations in which the HIV epidemic is still in its early phases (St. Petersburg) and in which the epidemic has matured (Brooklyn and Connecticut). Second, it has HIV prevention research management skills and on-site expertise needed to recruit and retain these populations in prevention intervention trials. Third, it has the national and international theoretical and practical scientific expertise to assist the HPTN in carrying out its extensive and complex mandate. Fourth, the EPTU has the capacity to expand to increase the number of high-risk or infected individuals for enrollment in larger prevention intervention studies. The Yale/MCW/SPSU St. Petersburg AITRPP has established linkage points with critical non-governmental organizations (NGOs) throughout Russia concerned about AIDS. The AITRP at SUNY-DMC has similar connections that can foster expansion to sites in Poland. Project SIDA in Kinshasa, Congo, is an additional possible collaborator that could be brought into the EPTU should HPTN supplemental funds become available at a later date.

描述（改编自申请人的摘要）：本申请提出 组建一个四机构联盟，即东部预防试验组 （EPTU）由耶鲁大学公共卫生学院（康涅狄格州纽黑文）组成， 纽约州立大学/下州医疗中心 (SUNY-DMC)（布鲁克林， 纽约），艾滋病生物医学中心/圣。圣彼得堡国立大学（SPSU）（圣彼得堡） 俄罗斯圣彼得堡）和艾滋病干预研究中心（CAIR） 威斯康星医学院 (MCW)（威斯康星州密尔沃基）。 调查人员 建议居住在合适的个人加入 HPTN 协议 康涅狄格州、布鲁克林和俄罗斯圣彼得堡。 MCW 将做出贡献 EPTU 的基于社区的行为干预研究的专业知识， 特别是在俄罗斯。 所有四个机构都有重叠的地理区域 和美国东部艾滋病毒预防的研究兴趣（正在进行的联合 研究）和东欧（艾滋病国际培训和研究计划 俄罗斯 [Yale/MCW/SPSU] 和东欧 [SUNY-DMC]）。 EPTU 可以 通过以下方式为 HPTN 做出贡献： (1) 确定有效的预防策略； (2) 通过该股的大型国际组织促进其评估 人口容量（康涅狄格州和布鲁克林人口基数为 600 万） 圣彼得堡有 600 万）。 这一人口基数的很大一部分人 政治、经济、社会和其他因素驱动的艾滋病毒高发病率 人口不稳定。 该应用程序将提议的四个显着优势归因于 财团。 首先，它可以为感染艾滋病毒的人群提供接触机会 疫情仍处于早期阶段（圣彼得堡），其中 流行病已经成熟（布鲁克林和康涅狄格州）。 其次，它有艾滋病毒 招聘所需的预防研究管理技能和现场专业知识 并将这些人群保留在预防干预试验中。 第三，它有 国内和国际理论和实践科学专业知识 协助 HPTN 执行其广泛而复杂的任务。 第四， EPTU 有能力扩展以增加高风险或 感染个体参加更大规模的预防干预研究。 耶鲁大学/MCW/圣彼得堡 SPSU AITRPP 已与以下机构建立了联系点： 俄罗斯各地重要的非政府组织 (NGO) 对此表示关注 关于艾滋病。 SUNY-DMC 的 AITRP 也有类似的联系，可以促进 扩展到波兰的站点。 刚果金沙萨的 SIDA 项目是 可以引入 EPTU 的其他可能的合作者应该 HPTN 补充资金将在稍后提供。

项目成果

HIV prevalence, sociodemographic, and behavioral correlates and recruitment methods among injection drug users in St. Petersburg, Russia.

俄罗斯圣彼得堡注射吸毒者的艾滋病毒患病率、社会人口统计学和行为相关性以及招募方法。

• DOI: 10.1097/01.qai.0000220166.56866.22
• 发表时间: 2006
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Shaboltas,AllaV;Toussova,OlgaV;Hoffman,IrvingF;Heimer,Robert;Verevochkin,SergeiV;Ryder,RobertW;Khoshnood,Kaveh;Perdue,Tom;Masse,BenoitR;Kozlov,AndreiP
• 通讯作者: Kozlov,AndreiP