FASEB Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors

FASEB 核激素受体动态结构夏季会议

• 批准号: 7161308
• 负责人: E B THOMPSON
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7161308
• 关键词: genetic regulation; meeting /conference /symposium; nuclear receptors; protein structure function; travel

DESCRIPTION (provided by applicant): Nuclear hormone receptors (NHRs), one of the most abundant classes of transcriptional regulators in metazoans, regulate diverse functions, such as homeostasis, reproduction, development, or metabolism. The NHRs function as ligand activated transcription factors, thus providing a direct link between signaling molecules that control these processes and transcriptional responses. As NHRs bind small molecules which can easily be modified by drug design, and control functions associated with major diseases such as cancer, osteoporosis, diabetes etc, they are promising pharmacological targets. A rapidly growing interest in the field of NHRs is the dynamics of their structures. It is our intent to create the first meeting that focuses the attention of NHR experts on the dynamic structural nature of the receptors they study. The purpose of this meeting is to focus on the research in this area. This meeting will bring together experts from protein biophysics, who are using advanced biophysical techniques to study protein dynamics, with those working on NHR action & NHR structural studies, to spur thinking in our field on NHRs as dynamic rather than static structures. We hope that this meeting will broaden understanding of the dynamic structural nature of NHRs and provide the intellectual and technical foundation for the coming years of research that will translate structure into practical applications. The specific aims of this meeting includes: i) to bring together NHR experts with protein biochemists studying non-NHR systems. This will give the NHR field insights on thinking and methods otherwise obscure. ii) to broaden the number of scientists in the NHR field who are aware of the dynamic nature of NHRs, and to encourage more study of this area. In particular, to encourage participation of disadvantage minorities and women in this area of NHR work. iii) to share new findings on the dynamic nature of NHRs. This application seeks financial support for the Federation of American Societies of Experimental Biology (FASEB) Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors, to be held from July 8-13, 2006 at Tucson, AZ. This conference is structured to provide an optimal opportunity for cross-discipline interaction as well as a balanced treatise on the most contemporary and contentious problems in our field. Every possible effort have been/will be made to include maximum possible number of participants from women, disadvantage minorities, and young investigators groups.

描述（由申请人提供）： 核激素受体（NHRS）是后生动物中最丰富的转录调节剂之一，它调节了多种功能，例如稳态，繁殖，发育或代谢。 NHR作为配体激活转录因子的功能，因此在控制这些过程和转录响应的信号分子之间提供了直接联系。由于NHR结合了小分子，这些分子可以通过药物设计很容易修饰，并且与主要疾病（如癌症，骨质疏松症，糖尿病等）相关的控制功能，它们是有希望的药理靶标。对NHR的领域的迅速兴趣是其结构的动力学。我们打算创建第一次会议，将NHR专家的注意力集中在他们研究的受体的动态结构性质上。这次会议的目的是专注于该领域的研究。这次会议将将使用先进的生物物理技术研究蛋白质动力学的蛋白质生物物理学的专家与从事NHR作用和NHR结构研究的人一起召集，以刺激我们领域的NHRS作为动态而不是静态结构。我们希望这次会议将扩大对NHRS动态结构性质的理解，并为未来几年的研究提供了智力和技术基础，将结构转化为实际应用。这次会议的具体目的包括：i）将NHR专家与研究非NHR系统的蛋白质生物化学家一起。这将使NHR领域有关思维和方法的见解，否则会给您带来晦涩难懂。 ii）扩大了NHR领域中了解NHR的动态性质的科学家的数量，并鼓励对该领域进行更多研究。特别是为了鼓励 劣势少数民族和妇女参与NHR工作。 iii）分享有关NHRS动态性质的新发现。该申请为美国联合会寻求财政支持 实验生物学社会（FASEB）夏季关于核激素受体动态结构的夏季会议，将于2006年7月8日至13日在亚利桑那州图森举行。这次会议的结构是为跨学科互动提供最佳机会，以及关于我们领域最现代和有争议的问题的平衡论文。尽一切可能的努力将包括来自女性，劣势少数群体和年轻调查员团体的最大参与者。