Nuclear Receptors: Steroid Sisters

核受体：类固醇姐妹

• 批准号: 7059262
• 负责人: CAROLE R MENDELSON
• 金额: $ 1.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7059262
• 关键词: meeting /conference /symposium; nuclear receptors; travel

DESCRIPTION (provided by applicant): The overall goal of this conference is to provide the most important and up-to-date research in the nuclear receptor field. Topics presented will include the roles of nuclear receptors in physiologic and pathophysiologic states, in development and in regulation of metabolic processes. Nuclear receptor-coregulator interactions, mechanisms in chromatin remodeling and transcriptional activation and repression also will be addressed, as will mechanisms of extranuclear signaling by steroid receptors. The roles of coregulators and nuclear receptors as potential targets for drug discovery will be considered, as well as structural properties of receptor domains complexed with ligands, cofactors, and DNA. It is our objective to highlight the latest biological tools (e.g., animal models, novel ligands, structural information) and technologies (e.g., genomics, proteomics, ligand screening) available for nuclear receptor research and promote the productive interaction of scientists from academic institutions and industry. We will address actions of nuclear receptors in health and disease, and the use of this knowledge for development of new drugs for treatment of endocrine and metabolic diseases. The meeting venue also will facilitate the interaction of leading experts in the field with younger scientists and trainees, with a particular emphasis on the inclusion of under represented groups.

描述（由申请人提供）： 这次会议的总体目标是在核受体领域提供最重要和最新的研究。提出的主题将包括核受体在生理和病理生理状态，发育和代谢过程调节中的作用。还将解决核受体调节器的相互作用，染色质重塑中的机制以及转录激活和抑制作用，类固醇受体的外核信号传导的机制也将得到解决。将考虑核心节和核受体作为药物发现的潜在靶标的作用，以及与配体，辅助因子和DNA复合的受体结构域的结构特性。我们的目标是强调最新的生物学工具（例如动物模型，新型配体，结构信息）和技术（例如，基因组学，蛋白质组学，配体筛查）可用于核受体研究，并促进学术机构和工业的科学家的生产性相互作用。我们将解决核受体在健康和疾病中的作用，并将这种知识用于开发新药来治疗内分泌和代谢疾病。会议场所还将促进该领域领先的专家与年轻科学家和学员的互动，并特别着重于包含在代表群体下的群体。