8th International Symposium - Saga of the Genus Bordetella, 1906-2006

第八届国际研讨会 - 博德特氏菌属传奇，1906-2006

• 批准号: 7230901
• 负责人: ERIK L HEWLETT
• 金额: $ 1.2万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-22 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7230901
• 关键词: Brucellaceae; meeting /conference /symposium; travel

Bordetella pertussis (at that time called Haemophilus pertussis) was cultured for the first time in 1906, by Bordet and Gengou, at the Institute Pasteur, and the meeting described in this proposal will include celebration of the centennial for that important event. Other early members of the genus, B. bronchiseptica and B. parapertussis, were isolated in 1912 and 1938, respectively. The incidence of pertussis is, however, now increasing in the US and other parts of the world, despite active immunization programs with wide coverage. For example, the number of reported cases in the US was almost 12,000 in 2003, an increase of six-fold since 1980 and there were 18,957 cases reported to the CDC in 2004. This is attributable, at least in part, to increases in recognition and occurrence of adolescent and adult pertussis. Beyond the original bordetellae, B. avium is an important cause of respiratory infections in birds and is responsible for tremendous economic losses for the poultry industry. In addition, several new species within the genus, such as B. hinzii, B. holmesii, B. trematum and B. petrii, are not well characterized with regard to spectrum of disease, virulence factors or pathogenesis. The genomes for B. pertussis, B. parapertussis, B. bronchiseptica and B. avium have been sequenced and the data published. This proposal is requesting support for students and post-doctoral fellows to attend the Eighth International Symposium: Saga of the Genus Bordetella, to be held in November 2006 at the Institute Pasteur, Paris. The bordetella community is an especially open and collaborative collection of scientists and it is important to assure and support attendance of trainees at meetings such as this.

百日咳博德特氏菌（当时称为百日咳嗜血杆菌） 1906 年，Bordet 和 Gengou 在 巴斯德研究所，本提案中描述的会议将包括 庆祝这一重要事件的百年纪念。其他早 支气管败血博德特氏菌 (B. bronchiseptica) 和副百日咳博德特氏菌 (B. parapertussis) 属的成员 分别于 1912 年和 1938 年被隔离。百日咳的发病率是 然而，尽管 主动免疫规划覆盖面广。例如， 2003 年，美国报告的病例数接近 12,000 例， 自 1980 年以来增加了六倍，共报告了 18,957 例病例 CDC于2004年发布的报告。这至少部分归因于 青少年和成人百日咳的识别和发生。 除了原始的博德特氏菌之外，鸟博德氏菌也是导致 鸟类呼吸道感染，造成巨大的 给家禽业造成经济损失。此外，还有几个新物种 属内，例如 B. hinzii、B. holmesii、B. trematum 和 B. petrii， 在疾病谱、毒力方面没有得到很好的表征 因素或发病机制。百日咳博德特氏菌、副百日咳博德特氏菌的基因组， B. bronchiseptica 和 B. avium 已被测序并且数据 发表。 该提案请求对学生和博士后的支持 研究员参加第八届国际研讨会：属的传奇 Bordetella，将于 2006 年 11 月在巴黎巴斯德研究所举行。 Bordetella 社区是一个特别开放和协作的社区 科学家的集合，保证和支持很重要 受训人员参加此类会议的情况。