Neural-Immune Interactions: Pathological Mechanisms and Repair

神经免疫相互作用：病理机制与修复

• 批准号: 7162124
• 负责人: CAROLINE C WHITACRE
• 金额: $ 2.2万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162124
• 关键词: immune response; immune system; inflammation; meeting /conference /symposium; nervous system regeneration; neuroimmunomodulation; neuropathology; travel

DESCRIPTION (provided by applicant): This application is a request for partial support for the 9th FASEB Summer Research Conference on "Neural-Immune Interactions: Pathological Mechanisms and Repair" to be held in Tucson, AZ, August 5-10, 2006. This conference brings together scientists from a variety of backgrounds who are interested in the interactions between the nervous and the immune systems from a basic as well as clinical perspective. The 8th FASEB Summer Research Conference on this topic in 2004 saw a 57% increase in attendance over the 2002 meeting, a trend which indicates the growing interest in this interdisciplinary field. In the last decade, scientists from different disciplines became interested in the cross talk between the immune and nervous systems. Accumulating evidence suggests that immune factors and cells play a role in the CNS in normal and pathological conditions, and that the CNS regulates peripheral immune responses. Rapid advances make it necessary to re-evaluate a number of basic aspects of CNS-immune interactions, including anatomical, pathological, and reparative functions. Previously, interest in immune involvement in the nervous system was limited to CNS autoimmune diseases. Now, CNS trauma/spinal cord injury and neurodegenerative diseases such as Alzheimer's disease, HIV associated dementia, and amyotrophic lateral sclerosis (ALS) are recognized as having inflammatory components. At the 2006 FASEB meeting, we will explore the role of an innate adaptive immunity continuum in causing tissue damage and repair, how immune cells traffic to the brain and their participation in antigen presentation events, the role of inflammatory events in CNS trauma and how that inflammation can be controlled. The meeting will focus on pathological mechanisms resulting in disease as well as how damaged tissue can be repaired. We propose to invite 39 speakers who are recognized leaders in this field and to encourage the participation of junior investigators and trainees. This meeting provides a much needed platform for scientific discussions in both basic and clinical neuroimmunology.

描述（由申请人提供）：本申请是为 2006 年 8 月 5 日至 10 日在亚利桑那州图森举行的第九届 FASEB 夏季研究会议“神经免疫相互作用：病理机制和修复”提供部分支持的请求。会议汇集了来自不同背景的科学家，他们从基础和临床角度对神经系统和免疫系统之间的相互作用感兴趣。 2004 年关于这一主题的第八届 FASEB 夏季研究会议的出席人数比 2002 年会议增加了 57%，这一趋势表明人们对这一跨学科领域的兴趣日益浓厚。 在过去的十年中，来自不同学科的科学家对免疫系统和神经系统之间的相互作用产生了兴趣。 越来越多的证据表明，免疫因子和细胞在正常和病理条件下在中枢神经系统中发挥作用，并且中枢神经系统调节外周免疫反应。 快速的进展使得有必要重新评估中枢神经系统-免疫相互作用的许多基本方面，包括解剖学、病理学和修复功能。 此前，人们对神经系统免疫参与的兴趣仅限于中枢神经系统自身免疫性疾病。 现在，中枢神经系统创伤/脊髓损伤和神经退行性疾病，如阿尔茨海默氏病、艾滋病毒相关痴呆和肌萎缩侧索硬化症 (ALS) 被认为具有炎症成分。 在 2006 年 FASEB 会议上，我们将探讨先天适应性免疫连续体在引起组织损伤和修复中的作用、免疫细胞如何运输到大脑及其参与抗原呈递事件、炎症事件在中枢神经系统创伤中的作用以及如何炎症是可以控制的。 会议将重点讨论导致疾病的病理机制以及如何修复受损组织。 我们建议邀请 39 位该领域公认的领导者进行演讲，并鼓励初级研究人员和实习生的参与。 这次会议为基础和临床神经免疫学的科学讨论提供了一个急需的平台。