11th International Symposium on Bordetella

第11届博德特氏菌国际研讨会

• 批准号: 9053803
• 负责人: ERIK L HEWLETT
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-08 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9053803
• 关键词: Address; Advertising; Animals; Area; Argentina; Awareness; Back; Bordetella; Bordetella pertussis; Case Study; Cells; Child; Clinical; Communities; Consensus; Country; Developing Countries; Diagnostic Sensitivity; Disease; Disease Outbreaks; Epidemiology; Etiology; Event; Exercise; Funding; Funding Opportunities; Future; Human; Immune response; Individual; Infant; Infection; International; Manufacturer Name; Medical; Microbiology; Notification; Organism; Participant; Pathogenesis; Pertussis; Pertussis Vaccine; Physicians; Postdoctoral Fellow; Prevention; Process; Public Health; Recording of previous events; Recovery; Request for Applications; Research; Research Personnel; Schedule; Scientist; Series; Special Event; Time; Travel; Underrepresented Minority; Vaccine Antigen; Vaccines; Virulence Factors; Whole Cell Vaccine; clinical epidemiology; graduate student; meetings; programs; public health relevance; symposium; transmission process; vaccine development; web site

 DESCRIPTION (provided by the applicant): Pertussis, caused primarily by Bordetella pertussis, is a contemporary public health problem in the US and worldwide. With >48,000 cases reported in the US in 2012, it is the least well controlled of the "vaccinepreventable" diseases, despite excellent coverage with acellular pertussis vaccines. While there are several hypotheses for these increases in clinical pertussis, such as increased public and medical awareness, enhanced diagnostic sensitivity and adaptation of the causal organism, it is clear that the acellular pertussis vaccines elicit protection of significantly shorter duration and diffeent type than previously used whole cell vaccines or recovery from past infection.For these reasons, the upcoming 11th International Bordetella Symposium, scheduled for April 2016 in Buenos Aires, Argentina, is particularly timely. These meetings take place on a three-four year cycle and are generally attended by 200-300 individuals (basic scientists, physicians, public health officials, vaccine manufacturers and representatives of regulatory agencies) from multiple countries; this level of participation reflects enthusiasm of the international Bordetella Research Community for this event. The major topics of discussion (see preliminary program) at this include: pertussis epidemiology and pathogenesis, immune responses and mechanisms of clearance in natural disease and following vaccine (in animals and humans) and B. pertussis strains not expressing virulence factors/vaccine antigens. Since there appear to be multiple factors (such as disparate immune response from natural disease, emergence of circulating strains not expressing vaccine antigens and possible transmission from asymptomatic hosts) contributing to the resurgence of pertussis, this meeting will provide an ideal forum for discussion of these possibilities and how to deal with the problem definitively. Thus the final session as round table discussion and consensus building exercise will be an important culmination/product from this special event with participants representing relevant areas of expertise for identifying solutions and next steps.

 描述（由应用程序证明）：百日咳，主要是由Bordetella Distussis引起的，这是一个现代的公共卫生问题。与细胞百日咳疫苗相关，例如公众和医疗危险增加，诊断敏感性增强并适应因果生物体，疫苗疫苗对持久性疫苗的明显持久和不同类型的类型造成了整体疫苗的影响。国际Bordetella研讨会，2016年4月在布宜诺斯艾利斯，尤其及时。 此事件的社区。因子/疫苗抗原。 。