Conference--Systems Biology Methods & Environment Resear

会议--系统生物学方法

• 批准号: 7001850
• 负责人: John B Barnett
• 金额: $ 0.6万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001850
• 关键词: bioinformatics; biological models; data collection methodology /evaluation; environmental exposure; environmental toxicology; functional /structural genomics; meeting /conference /symposium; proteomics; travel

DESCRIPTION (provided by applicant) Systems biology has become a major field -coming on the heels of the rise in prominence and acceptance of genomics and proteomics. Toxicoproteomics and toxicogenomics are become increasing important techniques in the arsenal of toxicologists -allowing us to assay the effects of environmental xenobiotics ultimately on the entire genome or proteome instead of isolated genes and their products. The role of systems biology in this paradigm is to develop and deploy the "tools" needed to analyze the vast amounts of data that is generated using these techniques. These tools include new bioinformatic techniques for analyzing these data to determine which genes and/or their products that have been altered by the environmental agents but also modeling software that allow us to conduct experiments in silica. In silica modeling will likely be instrumental in the understanding of the toxicology of mixtures. The purpose of this conference is to provide a mechanism for the effective exchange of ideas and methods between scientists that are conducting toxicoproteomics, toxicogenomics, bioinformatics and biological modeling environmental research. The overall plan for the agenda is to highlight relevant environmental exposure models that are appropriate for new toxicogenomic/toxicoproteomic data collection, presentations and discussion of cutting-edge research using toxicogenomics and toxicoproteomics and then follow this with presentations on state-of-art bioinformatic programs and techniques. Finally, the latest biological modeling tools will be introduced and discussed. The general plan also calls for the allocation of a 50 minute time block for a plenary presentation for each session, reserving approximately 10 minutes of that time for questions and discussion. The plenary presentation will be followed by three 30 minute presentations, each with a 10 minute question time. The session will be concluded with a panel discussion led by the primary speaker/chair. The advantage of smaller meetings, such as this, is that they are more conducive to discussion and exchange of ideas in contrast to larger national meeting formats, e. g., Society of Toxicology (SOT). The final session is reserved for presentations by representatives of commercial companies to highlight state-of-art equipment that will allow toxicologists to perform environmental research. We plan to contact editors of relevant journals to find a venue to publish the proceedings of this conference, thus, the benefactors of this conference will extend far beyond the participants of the conference to environmental researchers worldwide.

描述（由申请人提供） 随着基因组学和蛋白质组学的重要性和接受度的提高，系统生物学已成为一个主要领域。 毒物蛋白质组学和毒物基因组学已成为毒理学家武器库中越来越重要的技术，使我们能够最终分析环境外源物对整个基因组或蛋白质组的影响，而不是孤立的基因及其产物。 系统生物学在这一范式中的作用是开发和部署分析使用这些技术生成的大量数据所需的“工具”。 这些工具包括用于分析这些数据以确定哪些基因和/或其产物已被环境因素改变的新生物信息学技术，以及允许我们在二氧化硅中进行实验的建模软件。 在二氧化硅中，建模可能有助于理解混合物的毒理学。 本次会议的目的是为从事毒物蛋白质组学、毒物基因组学、生物信息学和生物建模环境研究的科学家之间有效交流思想和方法提供一个机制。 议程的总体计划是强调适用于新的毒物基因组学/毒物蛋白质组学数据收集、演示和讨论使用毒物基因组学和毒物蛋白质组学的前沿研究的相关环境暴露模型，然后介绍最先进的生物信息学项目和技术。 最后，将介绍和讨论最新的生物建模工具。 总体计划还要求为每次会议分配 50 分钟的全体会议发言时间，并预留大约 10 分钟的时间用于提问和讨论。 全体会议演讲之后将进行三场 30 分钟的演讲，每场演讲有 10 分钟的提问时间。 会议将以由主要发言人/主席主持的小组讨论结束。 诸如此类的小型会议的优点在于，与大型全国会议形式（例如会议）相比，它们更有利于讨论和思想交流。例如，毒理学会（SOT）。 最后一场会议由商业公司代表进行演讲，以突出毒理学家能够进行环境研究的最先进的设备。 我们计划联系相关期刊的编辑，寻找出版本次会议论文集的地点，这样，本次会议的受益者将远远超出会议的参与者范围，扩展到全世界的环境研究人员。