Colorado HNC SPORE Data Sciences Core

科罗拉多州 HNC SPORE 数据科学核心

基本信息

批准号：
10477445
负责人：
Dexiang Gao
金额：
$ 13.46万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10477445
关键词：
Animal Experiments Area Award Basic Science Bioinformatics Bioinformatics Shared Resource Biological Markers Biometry Categories Cells Clinic Clinical Data Clinical Research Clinical Trials Clinical Trials Design Collaborations Colorado Communication Community of Practice Data Analyses Data Collection Data Science Data Science Core Development Doctor of Philosophy Ensure Epidemiologist Evaluation Experimental Designs Extramural Activities Faculty Focus Groups Formulation Genetic Genetic Transcription Genomics Grant Head and Neck Cancer Head and neck structure Human Resources Immunological Models Immunotherapy In Vitro Individual Informatics Investigation Laboratories Lead Leadership Link Malignant Neoplasms Manuscripts Methods Mission Multiomic Data Mus Observational Study Outcome Paper Pathology Peer Review Play Population Study Predictive Value Preparation Process Proteins Proteomics Publishing Radiation Recording of previous events Reporting Research Research Design Research Methodology Research Personnel Research Support Resources Retrieval Ribosomes Role Sample Size Services Speed Statistical Models Structure T cell receptor repertoire sequencing T-Lymphocyte Techniques Testing The University of Colorado Cancer Center Therapeutic Time Translating Translational Research Universities anticancer research base career data management database design density design effectiveness research electronic data capture system experience improved in vivo innovation large datasets member next generation novel pre-clinical research preclinical study predictive modeling prognostic value programs quality assurance response single cell mRNA sequencing single-cell RNA sequencing small molecule software development therapeutic target tool trafficking translational study whole genome

项目摘要

SUMMARY, Data Science Core The University of Colorado Head and Neck Cancer (CO HNC) SPORE Data Science Core (DSC) provides services for biostatistics, informatics, bioinformatics, and other data science related analyses. The DSC staff is comprised of five Ph.D. and one Master’s level researchers who collectively offer substantial expertise in clinical trial design and analysis; statistical genetics, multi-omics data analysis; software development; predictive modeling; and cancer-focused bioinformatics. The core includes a comprehensive team of biostatisticians, bioinformaticians, and an epidemiologist, that form a hub of researchers with the common denominator of being engaged in HNC research through exisiting collaborations. The DSC has the overarching objective to build a community of practice related to HNC data science. All staff are operationally managed and overseen by the DSC Director, Dexiang Gao Ph.D, and like all faculty in the CO HNC SPORE the DSC faculty are members of the University of Colorado Cancer Center (UCCC), specifically the Biostatistical and Bioinformatics shared resource (BBSR). The BBSR has a long-standing history of collaboration with the Head and Neck research team over the past 10 years. Faculty biostatisticians and bioinformaticians are engaged in the development of novel methods and tools that enhance the HNC SPORE. Since 2015, faculty within the DSC published ~20 peer- reviewed manuscripts (with an additional 5 in preparation) and collaborated on 9 peer-reviewed extramural R01 grants with HNC SPORE investigators, 4 of which are active awards. By harnessing these established collaborations, the DSC can effectively and efficiently support CO HNC SPORE projects. Integrating personnel within a Core to support all SPORE programs will maximize available resources to increase the DSC’s scientific impact. Specifically, the DSC will provide assistance with research hypotheses formulation, clinical trial designs, sample size determination, analytical and database design, data collection, analyses, management and storage. This support will continue through management and coordination of accumulating research and clinical data analyses, assistance with manuscript preparation and clinical trial reports in relation to key quantitative findings and rigorous scientific conclusions. Thus, the DSC will play a critical role in clinical trials, as well as basic science and translational studies.

摘要，数据科学核心科罗拉多大学头颈癌 (CO HNC) SPORE 数据科学核心 (DSC) 提供 DSC 工作人员为生物统计学、信息学、生物信息学和其他数据科学相关分析提供服务。由五名博士和一名硕士水平的研究人员组成，他们共同提供丰富的临床专业知识试验设计和分析；统计遗传学、多组学数据分析；核心包括生物统计学家综合团队，生物信息学家和流行病学家，形成了研究人员的中心，其共同点是通过现有的合作参与 HNC 研究，DSC 的总体目标是建立一个与 HNC 数据科学相关的实践社区。所有员工均由 HNC 进行运营管理和监督。 DSC 主任、高德祥博士，与 CO HNC SPORE 的所有教职人员一样，DSC 教职人员也是科罗拉多大学癌症中心 (UCCC)，特别是生物统计和生物信息学共享 BBSR 与头颈研究团队有着悠久的合作历史。在过去的10年里，生物统计学家和生物信息学家致力于新颖的开发。增强 HNC SPORE 的方法和工具自 2015 年以来，DSC 的教师发表了约 20 篇同行文章。审阅手稿（另外 5 篇正在准备中）并合作完成 9 篇经过同行评审的校外 R01 与 HNC SPORE 研究人员共同获得资助，其中 4 项是积极奖励。通过合作，DSC 可以有效、高效地支持 CO HNC SPORE 项目的人员整合。支持所有 SPORE 计划的核心将最大限度地利用可用资源，以提高 DSC 的科学能力具体来说，DSC 将在研究假设制定、临床试验设计、样本量确定、分析和数据库设计、数据收集、分析、管理和存储。这种支持将通过管理和协调积累的研究和临床数据继续下去分析、协助准备稿件和与关键定量结果相关的临床试验报告因此，DSC 将在临床试验和基础科学中发挥关键作用。和转化研究。