RR&D Research Career Scientist Award Application - Renewal of Margot Damaser SRCS Award

基本信息

批准号：
10686071
负责人：
MARGOT S. DAMASER
金额：
--
依托单位：
LOUIS STOKES CLEVELAND VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-01 至 2028-09-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686071
关键词：
Acceleration Activities of Daily Living Advisory Committees Affect Agreement American Animal Experiments Animal Model Animals Area Award Biomedical Engineering Birth trauma Bladder Book Chapters Books Breakthrough device Caring Catheters Central Nervous System Diseases Clinic Clinical Collaborations Conscious Constipation Development Device Designs Device or Instrument Development Devices Diabetes Mellitus Diagnosis Disease Elderly Electric Stimulation Engineering Evaluation Exercise Extravasation Fecal Incontinence Female Foundations Functional disorder Funding Goals Grant Grant Review Gymnastics Homing Human IACUC Impairment Interdisciplinary Study Intestines Investments Joints Journals Kidney Laboratory Research Legal patent Licensing Manuscripts Massachusetts Measures Medical Medical Device Medicine Mentors Methods Modeling Monitor Motivation Multiple Trauma Muscle Nanotechnology Natural regeneration Nerve Neurogenic Bladder Ohio Organ Paper Parachuting Pelvic Floor Disorders Pelvic floor structure Physical activity Physiology Positioning Attribute Prevalence Productivity Publishing Recovery Reference Standards Regenerative Medicine Rehabilitation therapy Research Research Personnel Research Project Grants Resistance Rodent Role Running Scientific Societies Scientist Services Source Spinal cord injury Stress Urinary Incontinence System Technology Testing Training Translating Translational Research Translations Traumatic Brain Injury United States Department of Veterans Affairs United States National Institutes of Health Universities Urethra Urinary Incontinence Urology Vagina Veterans Weight Weight Lifting Woman career clinical translation college diabetic human subject improved innovation member minimally invasive nerve injury neurotrophic factor novel overexpression pelvic organ prolapse peripheral nerve regeneration professor programs regenerative regenerative approach rehabilitation research research and development research in practice stem cells technology platform translational potential wireless

项目摘要

Summary/Abstract Dr. Margot Damaser is Senior Research Career Scientist in the RR&D Service of the US Department of Veterans Affairs and Professor of Biomedical Engineering in the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. She is Deputy Director and co-PI of the Advanced Platform Technology Center. Dr. Damaser's research is focused on using principles of engineering, physiology, and regenerative medicine to develop new models and devices for improvement of diagnosis, treatment, and rehabilitation of pelvic floor disorders (PFD): urinary incontinence, fecal incontinence, and pelvic organ prolapse. Rehabilitation of these autonomic organs is an understudied field with great relevance to Veterans, particularly women and those with spinal cord injury or neurogenic disorders. She has initiated development of novel wireless catheter- free technology for monitoring bladder and bowel function during conscious ambulation and activities of daily living. This innovative monitoring system provides a paradigm shift in diagnosis, rehabilitation, and treatment of urinary and fecal incontinence, constipation and voiding dysfunction. In addition, her research focuses on regenerative approaches to treat PFD, including stem cells and/or their secretions, electrical stimulation, and elastogenic nanotechnology. She has made significant advances in this area by demonstrating that treatment with the secretions from stem cells is highly regenerative even when the treatment is given systemically, suggesting minimal invasive therapy could be utilized. In addition, she has demonstrated that electrical stimulation can regenerate peripheral nerves even in situations of impaired regeneration. These treatments are promising to promote rehabilitation, particularly for Veterans with impaired regeneration, such as the elderly, diabetics, and those with polytrauma affecting both nerves and muscles. The over-arching goals of this research is to benefit Veterans. To that end Dr. Damaser has invested effort to translate technology and has 4 issued patents, 3 pending patents, and 1 provisional patent application, as well as 2 licensed technologies, 1 option to license a technology, 1 joint development agreement, and 1 evaluation agreement with multiple companies in the field. In 2019, Dr. Damaser was 1st Place winner for the UroMonitor in the Massachusetts Medical Device Development (M2D2) $200k Challenge, demonstrating the translational potential of her technology. She is thus on track to translate novel diagnosis, treatment and rehabilitation methods to the clinic within the next 10 years. She has obtained funding for her research from VA, NIH, DOD, the State of Ohio, and foundation and corporate sources. In recognition of the significance of her research, Dr. Damaser was elected to the American Institute for Medical and Biological Engineering (AIMBE) in 2014. During the current SRCS award period, Dr. Damaser published 37 research manuscripts, 19 review papers and 4 book chapters. She co-edited a book that has become a standard reference in the field and mentored many young investigators. Dr. Damaser is currently Deputy Director and co-PI of the Advanced Platform Technology Center (2 I50 RX001871), PI of an NIH R21 grant, (R21HD095234), PI of an NIH Other Transaction Award (NIH OT2 OD023873), and co- Investigator on multiple NIH and foundation grants. She served for 12 years as Chair of the local IACUC (2008- 2020) and serves as a member of the Field Advisory Committee to VA ORO in addition to serving on multiple VA and NIH grant review panels. In addition, she uses her research program to train many clinical, scientific, and engineering trainees in research practices, enlarging the impact of her research. In recognition of this effort, Dr. Damaser was awarded the Urology Care Foundation Distinguished Mentor Award in 2020. In her role as co-PI and Deputy Director of the APT Center, Dr. Damaser is in a position to expand her influence to mentor others in conducting productive translational rehabilitation research and development during the upcoming renewal period of her Senior Research Career Scientist Award.

摘要/摘要 Margot Damaser博士是美国RR＆D服务的高级研究职业科学家退伍军人事务和克利夫兰诊所伦纳医学院的生物医学工程教授案例西部储备大学。她是高级平台技术的副总监兼副总监中心。 Damaser博士的研究专注于使用工程，生理学和再生原理医学来开发新的模型和设备，以改善诊断，治疗和康复骨盆底疾病（PFD）：尿失禁，粪便失禁和骨盆器官脱垂。康复这些自主器官中有一个研究的领域，与退伍军人，尤其是妇女和患有脊髓损伤或神经源性疾病的人。她启动了新型无线导管的发展 - 在有意识的移动和每日活动期间，用于监测膀胱和肠功能的免费技术活的。这种创新的监测系统提供了诊断，康复和治疗的范式转移尿液和粪便尿失禁，便秘和功能障碍。此外，她的研究重点是治疗PFD的再生方法，包括干细胞和/或其分泌物，电刺激以及弹性纳米技术。她通过证明治疗方面在这一领域取得了重大进步即使从系统地给予治疗，干细胞的分泌也很高建议可以使用最小的侵入性疗法。此外，她已经证明了电气即使在再生受损的情况下，刺激也会再生周围神经。这些治疗方法是有望促进康复，特别是对于老年人等再生的退伍军人，糖尿病患者以及患有多发性神经的多发性糖尿病患者。这项研究的总体目标是为了使退伍军人受益。为此，达马瑟（Damaser）博士已经投入了努力来翻译技术，并已发行了4个专利，3份未申请专利和1项临时专利申请，以及2项许可技术，1个选项许可技术，1个联合发展协议和1个评估协议与多家公司领域。 2019年，达马瑟博士在马萨诸塞州医疗设备开发（M2D2）$ 200K挑战，证明了她技术的翻译潜力。因此，她有望将新颖的诊断，治疗和康复方法转化为诊所接下来的10年。她从VA，NIH，DOD，俄亥俄州和基金会获得了研究资金和公司来源。为了表彰其研究的重要性，达马瑟博士当选为 2014年美国医学与生物工程研究所（AIMBE）。时期，达马瑟（Damaser）博士发表了37篇研究手稿，19条评论论文和4本书章节。她共同编辑这本书已成为该领域的标准参考，并指导了许多年轻的调查员。达马瑟博士目前是高级平台技术中心（2 I50 RX001871）的副主任兼Co-Pi， NIH R21 Grant，（R21HD095234），NIH其他交易奖（NIH OT2 OD23873）的PI，以及共同多个NIH和基金会补助金的研究者。她担任当地IACUC主席（2008-- 2020年），并担任VA OO现场咨询委员会成员 VA和NIH赠款评论面板。此外，她使用她的研究计划来培训许多临床，科学，以及研究实践的工程学员，扩大了她的研究影响。认识到这项努力，达马瑟博士于2020年被授予泌尿外科护理基金会杰出导师奖。作为APT中心的共同PI和副主任，Damaser博士可以将她的影响力扩大到导师其他人在即将到来的她的高级研究职业科学家奖的更新期。