Structural Genomics

结构基因组学

• 批准号: 7000544
• 负责人: Cheryl H Arrowsmith
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000544
• 关键词: functional /structural genomics; meeting /conference /symposium; protein structure; travel

DESCRIPTION (provided by applicant): The 2006 Keystone Structural Genomics Meeting will provide a venue for discussion of progress and technical advances in the field of rapid, parallel, and economically efficient methods for structural biology. Keynote and Invited Speakers are all thought leaders in the areas of Bioinformatics, Protein Expression/ Purification, Sample Preparation, X-ray Crystallography, Solution NMR Spectroscopy, Biophysical characterization of proteins, Functional Annotation, and Structure-Based Drug Discovery. Keynote and Regular Sessions cover the following topics: - Selection of targets that both increase our knowledge of protein structure and enhance biomedical research. - Efficient parallel methods for sample preparation for solution NMR spectroscopy and X-ray crystallography. - Automated data reduction, structure determination, refinement, and data deposition. - Computational and experimental approaches to functional annotation of new protein structures. - Insights into structure, function and evolution of protein gene families. - Applications of high-throughput structural studies to important biomedical problems and drug discovery. Poster Sessions provide opportunity for presentations by conferees, particularly Younger Scientists, as well as detailed presentations by Structural Genomics Centers and Consortia throughout the world. Proteins are the molecular machines that make up and carry out the work of a cell. They are also the targets for most therapeutic drugs. This meeting will focus on methods and strategies to rapidly and efficiently determine the 3-dimensional shapes of all proteins so that we better understand how they work and how to harness them for therapeutic purposes.

描述（由申请人提供）：2006年Keystone结构基因组学会议将为讨论快速，平行和经济上有效生物学方法的进步和技术进步的讨论场所。主题演讲者和受邀讲话者都是生物信息学，蛋白质表达/纯化，样品制备，X射线晶体学，溶液NMR光谱，蛋白质的生物物理表征，功能注释和基于结构的药物发现的领域。主题演讲和常规会议涵盖了以下主题： - 选择既可以提高我们对蛋白质结构知识又增强生物医学研究的目标的选择。 - 用于溶液NMR光谱和X射线晶体学的样品制备的有效平行方法。 - 自动数据减少，结构确定，改进和数据沉积。 - 新蛋白质结构功能注释的计算和实验方法。 - 对蛋白质基因家族的结构，功能和演变的见解。 - 高通量结构研究应用于重要的生物医学问题和药物发现。海报会议为联合国，特别是年轻科学家的演讲提供了机会，以及全世界结构基因组学中心和财团的详细演讲。蛋白质是构成和执行细胞工作的分子机器。它们也是大多数治疗药物的靶标。这次会议将侧重于快速有效地确定所有蛋白质的三维形状的方法和策略，以便我们更好地了解它们的工作方式以及如何用于治疗目的。