Membrane Organisation by Tetraspanins and Small Multi-transmembrane

四跨膜蛋白和小型多跨膜的膜组织

• 批准号: 7162144
• 负责人: Tung-Tien Sun
• 金额: $ 1.1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162144
• 关键词: meeting /conference /symposium; protein structure function; tetraspanin; travel

We request partial funding for a FASEB conference on "Membrane Organization by Tetraspanins and Small Multi-transmembrane Proteins" to be held at Omni Tucson National Golf Resort and Spa, Tucson, Arizona, July 22-27 2006. A major theme in this tetraspanin conference is the roles of these proteins in the immune system. Tetraspanins, including CD9, CD37, CD53, CD63, CD81, CD82, CD151 and TSSC6, are involved in all the major cells and processes of the immune system. Thus, they have a role in regulating humoral immunity, B cell migration, plasma cell establishment, T cell receptor signaling and costimulatory signals, antigen presentation, adhesion and migration of neutrophils, and leukocyte transendothelial migration. These tetraspanin functions have implications for immunity problems including autoimmune diseases, blood cell neoplasm, allergen-induced hypersensitivity, inflammation, and autoimmune manifestations associated with hepatitis C. Many tetraspanins can regulate the signaling and membrane compartmentalization of their partner proteins, which include integrins, T cell receptor, and growth factor receptors. In addition, tetraspanins play a role in the development and function of neural cells, and they can serve as the receptors for viral and bacterial pathogen. Therefore, tetraspanins play a role not only in the immune system, but also in cancer, neurological and infectious diseases. Mechanistic understanding of tetraspanin function is only recently becoming evident. One exciting new understanding is that tetraspanins form unique membrane microdomains analogous to the glycosphingolipid enriched "rafts" which serve to partition membrane components and proteins. In addition, growing evidence suggests that these microdomains may mediate membrane fusion events. This truly unique FASEB conference will bring together researchers from a rich diversity of specializations to present and discuss the latest advances in tetraspanin research. The attending investigators generally do not encounter one another at meetings within their disciplines and there is no other venue at which this highly interdisciplinary subject is addressed. This conference will provide a unique opportunity for the exchange of ideas, reagents and discoveries across disciplinary boundaries and is expected to foster collaborations, which form the basis of significant advances in understanding tetraspanin biology.

我们要求为Faseb关于“膜组织的Faseb会议”的部分资金 四跨果蛋白和小型多跨膜蛋白”将在Omni Tucson保存 国家高尔夫度假村和水疗中心，亚利桑那州图森，2006年7月22日至2006年。这是一个主要主题 四跨果蛋白会议是这些蛋白质在免疫系统中的作用。四翼胺， 包括CD9，CD37，CD53，CD63，CD81，CD82，CD151和TSSC6涉及 免疫系统的所有主要细胞和过程。因此，他们在 调节体液免疫，B细胞迁移，浆细胞的建立，T细胞受体 信号传导和共刺激信号，抗原表现，粘附和迁移 中性粒细胞和白细胞跨内皮迁移。这些四翼烷敏的功能具有 对免疫问题的影响，包括自身免疫性疾病，血细胞肿瘤， 过敏原引起的高敏性，炎症和自身免疫性表现 与丙型肝炎有关。许多四叠腺苷可以调节信号传导和膜 其伴侣蛋白的隔室化，其中包括整联蛋白，T细胞受体， 和生长因子受体。此外，四跨载质在开发中发挥了作用， 神经细胞的功能，它们可以用作病毒和细菌的受体 病原。因此，四翼胺不仅在免疫系统中起作用，而且在 癌症，神经和传染病。四翼胺的机械理解 功能直到最近才变得明显。一个令人兴奋的新理解是 四跨载质形成类似于糖磷脂类似的独特膜微域 富集的“筏”，可用于分配膜成分和蛋白质。此外， 越来越多的证据表明，这些微区可能介导膜融合 事件。这个真正独特的Faseb会议将使来自富人的研究人员聚集在一起 介绍和讨论四面质蛋白的最新进展的专业多样性 研究。参加的调查人员通常不会在会议上互相遇到 在他们的学科中，没有其他地点这个高度跨学科的场所 主题已解决。这次会议将为交流提供独特的机会 跨学科界限的思想，试剂和发现，并有望促进 合作，构成了理解四翼胺的重大进展的基础 生物学。