Alcohol Biomarkers in General Clinical Settings

一般临床环境中的酒精生物标志物

• 批准号: 7124756
• 负责人: MICHAEL F. FLEMING
• 金额: $ 13.33万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124756
• 关键词: alcoholism /alcohol abuse; alcoholism /alcohol abuse prevention; attention deficit disorder; behavioral /social science research tag; biomarker; blood chemistry; blood protein disorder; carbohydrate balance; clinical research; clinical trials; data collection methodology /evaluation; drug abuse; emergency care; fetal alcohol syndrome; health economics; hospital length of stay; hospital patient care; human morbidity; human subject; immunologic assay /test; medical complication; outcomes research; psychometrics; tobacco abuse; transferrin; trauma

DESCRIPTION (provided by applicant): Background: Dr. Fleming has spent the majority of the last 15 years conducting alcohol research, mentoring alcohol researchers, caring for patients and providing consultation to physicians and health care leaders. The PI is committed to continuing his work in the area of patient-oriented research, mentoring, leadership and patient care for the remainder of his academic career. Dr. Fleming is committed to addressing the critical shortage of physician scientists conducting research in the alcohol area. Goal of K24 application: The goal of this application is to provide the PI with 25% time to mentor junior patient oriented investigators and develop new graduate school courses in clinical research as well as an additional 25% time to expand his research program into the areas of alcohol biomarkers, alcohol-related trauma and medication treatment of children with ADHD and fetal alcohol spectrum disorder. If the K24 is awarded in July 2005, he would be funded 40% time on two NIAAA funded R01 grants (R01AA012522-03 and R01AA014685-01), 10% time by his department for his clinical work and 50% time by the proposed K24 grant. Dr. Fleming is completing follow up work on three NIH grants that were completed in the fall of 2004 (R21AA013368-02, R01DA013686-02 and R01AA12664-01A2). Proposed mentoring activities: The K24 award will allow him to expand his research mentoring activities in the alcohol area to include new research fellows and graduate students. It would allow him to spend more time on his recently awarded new NIAAA T32 grant which will fund three physician scientists per year. This training program will focus on increasing the number of physicians who conduct NIAAA funded research. He plans to develop 1-2 new graduate school courses on how to conduct alcohol research with a focus on research methodology and analysis strategies. Significance: The proposed K24 complements the current NIH Roadmap Initiatives. The grant will facilitate Dr. Fleming's ability to train new physician scientists, develop graduate-level courses for masters and PhD students interested in clinical research as well as increasing his capacity to conduct translational research.

描述（由申请人提供）： 背景：弗莱明博士过去 15 年的大部分时间都在进行酒精研究、指导酒精研究人员、照顾患者以及为医生和医疗保健领导者提供咨询。 PI 致力于在其剩余的学术生涯中继续从事以患者为中心的研究、指导、领导和患者护理领域的工作。弗莱明博士致力于解决在酒精领域进行研究的医师科学家的严重短缺问题。 K24 应用程序的目标：此应用程序的目标是为 PI 提供 25% 的时间来指导以患者为导向的初级研究人员并开发新的临床研究研究生院课程，以及额外的 25% 的时间将其研究计划扩展到这些领域酒精生物标志物、酒精相关创伤和患有多动症和胎儿酒精谱系障碍的儿童的药物治疗。如果 K24 于 2005 年 7 月获得，他将获得两项 NIAAA 资助的 R01 拨款（R01AA012522-03 和 R01AA014685-01）的 40% 时间，10% 的时间由他的部门用于临床工作，50% 的时间由拟议的 K24 提供授予。 Fleming 博士正在完成 2004 年秋季完成的三项 NIH 资助项目（R21AA013368-02、R01DA013686-02 和 R01AA12664-01A2）的后续工作。 拟议的指导活动：K24 奖将使他能够扩大在酒精领域的研究指导活动，将新的研究员和研究生纳入其中。这将使他能够将更多的时间花在最近获得的新的 NIAAA T32 拨款上，该拨款每年将资助三名医师科学家。该培训计划将重点关注增加进行 NIAAA 资助研究的医生数量。他计划开发 1-2 个新的研究生课程，介绍如何进行酒精研究，重点是研究方法和分析策略。 意义：拟议的 K24 补充了当前 NIH 路线图计划。这笔赠款将有助于弗莱明博士培养新的医师科学家、为对临床研究感兴趣的硕士和博士生开发研究生水平的课程，以及提高他进行转化研究的能力。