ADHD and Alcohol Use: A Longitudinal Examination of Dual Processes

ADHD 和酒精使用：双重过程的纵向检查

基本信息

批准号：
10693830
负责人：
Amy Stamates
金额：
$ 18.78万
依托单位：
UNIVERSITY OF RHODE ISLAND
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10693830
关键词：
Address Affect Age Alcohol abuse Alcohol consumption Alcohols Attention Attention deficit hyperactivity disorder Automobile Driving Award Clinical Data Data Analyses Development Plans Diagnosis Ecological momentary assessment Educational workshop Environment Etiology Event Executive Dysfunction Gender Glass Goals Impulsivity Individual Intervention Knowledge Laboratories Location Maintenance Measurement Mental disorders Mentored Research Scientist Development Award Mentorship Methods Modeling National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Outcome Outcome Assessment Participant Persons Population Populations at Risk Predisposition Prevention Process Relapse Research Research Support Resources Rewards Risk Scientist Severities Strategic Planning Substance Use Disorder Time Training addiction alcohol behavior alcohol comorbidity alcohol craving alcohol intervention alcohol measurement alcohol related problem alcohol research alcohol risk alcohol use disorder career development contextual factors craving design drinking executive function experience innovation meetings peer peer influence programs sex skills social social factors symposium theories therapy development young adult

项目摘要

PROJECT SUMMARY The proposed Mentored Research Scientist Development Award (K01) will launch Dr. Amy Stamates’ program of research as an independent scientist focusing on the etiology of alcohol problems among young adults. This goal will be achieved through a 5-year parallel research and tailored training plan. Training goals include building expertise in (1) clinical knowledge of alcohol use; (2) executive functioning (EF) and attention- deficit/hyperactivity disorder (ADHD); (3) ecological momentary assessment (EMA); (4) advanced longitudinal data analyses; and (5) grantsmanship. Training goals will be met through a comprehensive training plan involving meetings with Drs. Lynda Stein (expert in alcohol interventions), Lisa Weyandt (expert in ADHD), Kristina Jackson (expert in EMA methods and analyses), and Timothy Wilens (expert in ADHD and substance use disorders); workshops; conferences; coursework; and experiential activities. Skills gained through the training plan will be put into action through a complementary research plan aimed to understand the alcohol- risk process of young adult drinkers with ADHD. Young adults with ADHD are at greater risk for experiencing alcohol problems (e.g., risky sex, driving after drinking) and developing alcohol use disorder (AUD) compared to those without ADHD. However, it is unclear why those with ADHD are at greater risk because research supports that they drink less than or equivalent to their non-ADHD peers. The proposed project will study this discrepancy by utilizing a measurement-burst design pairing laboratory and EMA to examine controlled (EF) and automatic (craving) processes in relation to alcohol use among those with and without ADHD. Participants (stratified by ADHD and gender) will be 141 young adult drinkers who complete three bursts over a one-year period (baseline, 6-months, and 12-months). Each timepoint will include a laboratory session assessing EF followed by 17 days of EMA assessing craving, alcohol use, alcohol problems, context, and social setting. The proposed project has three specific aims: (1) examine the impact of ADHD on EF and alcohol outcomes (craving, alcohol use, and alcohol problems) at baseline; (2) determine within-person changes between EF and alcohol outcomes over one year for those with and without ADHD; (3) identify event-level predictors (context, social setting) that heighten craving, alcohol use, and alcohol problems for those with ADHD. Findings from the proposal will provide preliminary data for a R01 application to be completed by Dr. Stamates during the award period. The proposed research seeks to address knowledge gaps of etiological factors underlying ADHD and AUD, with the ultimate goal to identify opportunities to tailor prevention and intervention approaches for young adults with ADHD. Thus, this proposal is in line with NIAAA’s 2017-2021 Strategic Plan for Research to investigate mechanisms underlying comorbid alcohol and psychiatric disorders. Completion of the K01 will provide Dr. Stamates with the expertise to conduct innovative, high-impact research focusing on the etiology of alcohol-related problems, particularly young adults with ADHD who may be most vulnerable.

项目摘要拟议的指导研究科学家发展奖（K01）将启动Amy Stamates博士的计划作为一名独立科学家的研究，重点介绍了年轻人的酒精问题的病因。这目标将通过为期5年的平行研究和量身定制的培训计划来实现目标。培训目标包括在（1）饮酒临床知识中建立专业知识；（2）执行功能（EF）和注意力 - 赤字/多动症（ADHD）；（3）生态瞬时评估（EMA）；（4）高级纵向数据分析；（5）授予技巧。培训目标将通过全面的培训计划实现涉及与博士的会面。 Lynda Stein（酒精干预专家），Lisa Weyandt（ADHD专家）， Kristina Jackson（EMA方法和分析专家）和Timothy Wilens（ADHD和基板的专家使用疾病）；讲习班；会议；课程工作；和专家活动。通过培训计划将通过一项完整的研究计划付诸实施，旨在了解酒精 - 患有多动症的年轻成年饮酒者的风险过程。患有多动症的年轻人面临更大的体验风险酒精问题（例如，有风险的性，饮酒后开车）和发展饮酒障碍（AUD）对于那些没有多动症的人。但是，目前尚不清楚为什么患有多动症的人会面临更大的风险，因为研究支持他们的饮酒小于或等同于非ADHD同龄人。拟议的项目将研究通过使用测量 - 爆炸设计配对实验室和EMA检查受控（EF），差异（EF）以及与ADHD的患者之间有关酒精使用的自动（渴望）过程。参与者（由多动症和性别分层）将是141名年轻饮酒者，他们在一年中完成三次爆发周期（基线，6个月和12个月）。每个时间点都将包括实验室会议评估EF 其次是EMA评估，饮酒，酒精问题，环境和社会环境的17天。拟议的项目具有三个具体目标：（1）检查多动症对EF和酒精结果的影响（渴望，饮酒和酒精问题）在基线时；（2）确定EF和EF之间的人身变化对于患有和没有多动症的人来说，酒精结果多一年；（3）确定事件级预测指标（上下文，社交环境）增加了多动症患者的渴望，饮酒和酒精问题。来自提案将为R01申请提供初步数据，由Stamates博士在奖励期间完成时期。拟议的研究旨在解决ADHD基础的病因因素的知识差异和 aud，最终目标是确定适合年轻人的预防和干预方法的机会患有多动症的成年人。这，该提案符合NIAAA的2017 - 2021年战略计划，用于研究研究合并症和精神疾病的基础机制。 K01的完成为Stamates博士提供专业知识，以进行创新的高影响力研究，重点介绍与酒精有关的问题，尤其是可能最脆弱的ADHD的年轻人。