Outcomes Research in Rheumatic Diseases: A Mentoring Program

风湿性疾病的结果研究：指导计划

• 批准号: 7258774
• 负责人: Maria E Suarez-Almazor
• 金额: $ 15.73万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7258774
• 关键词: Outcomes; Research; Rheumatic; Diseases; Mentoring

DESCRIPTION (provided by applicant): The aim of this application is to develop a patient-oriented mentoring and research program in rheumatic diseases at Baylor College of Medicine. By establishing a comprehensive methodological and content-based program we will provide mentorship and research opportunities to students, fellows, and junior physician and PhD Faculty interested in pursuing independent research careers in Outcomes Research and Clinical Epidemiology in rheumatic diseases. The proposed program will be interdisciplinary in nature and will be facilitated by the interaction between physicians and scientists in the Sections of Health Services Research and Immunology, Allergy and Rheumatology at Baylor College of Medicine. The applicant has MD and PhD degrees and is a rheumatologist and clinical epidemiologist. She is Faculty in both Baylor Sections. Her research interests are in the outcomes of rheumatic diseases, particularly rheumatoid arthritis and osteoarthritis, with an emphasis on the effectiveness of care in these disorders, patient and physician preferences and decision-making processes, and measurement of patient reported outcome in these diseases. The proposed program is based on current grants held by the applicant and the planned continuation projects arising from this research, including: (1) Decision-Making in Joint Replacement - Variations in the use of joint replacement are well documented. The aim of the study is to identify patient and physician determinants of this variation, and to develop evidence-based decision aids to assist patients in their decisions. (2) Treatment Adherence in Patients with Rheumatic Disease - We are conducting a prospective cohort study to evaluate treatment adherence in patients with rheumatoid arthritis and systemic lupus. Preliminary data shows that adherence is problematic. The results of the study will provide the groundwork for an evaluation of a multifaceted intervention to improve adherence. (3) Cognitive Determinants of Outcomes in Total Knee Replacement- Approximately 20-25% of patients undergoing knee replacement are not satisfied with the results, despite technical success. We are evaluating the clinical and psychosocial determinants of this dissatisfaction in a cohort of patients undergoing knee replacement. There is evidence that this may be related to deficient rehabilitation within the first three months after surgery. At the end of the study, we are planning to develop, implement and evaluate a perioperative intervention designed to improve outcomes through goal-setting and various other cognitive techniques. (4) Impact of Patient-Provider Interaction in the Response to Acupuncture in Patients with Knee Osteoarthritis - This is a randomized controlled trial comparing acupuncture and sham acupuncture in the treatment of knee osteoarthritis. The main aim of the study is to evaluate the effects of different patient-provider communication styles on acupuncture and placebo responses.

描述（由申请人提供）：本申请的目的是在贝勒医学院开发以患者为导向的辅导和研究计划。通过建立一个全面的方法论和基于内容的计划，我们将为学生，研究员以及初级医师和博士学位教师提供指导和研究机会，并有兴趣从事风湿病研究和临床流行病学的独立研究生涯。拟议的计划本质上是跨学科的，将由贝勒医学院的卫生服务研究与免疫学，过敏和风湿病学部分的医师与科学家之间的相互作用促进。申请人具有医学博士学位和博士学位，是风湿病学家和临床流行病学家。她是贝勒各个部分的教师。她的研究兴趣在于风湿性疾病的结果，尤其是类风湿关节炎和骨关节炎，重点是护理在这些疾病，患者和医师的偏好和决策过程中的有效性，以及这些疾病中患者报告的结果的测量。拟议的计划是基于申请人持有的当前赠款以及这项研究引起的计划的延续项目，包括： （1）关节置换中的决策 - 使用关节置换的变化已得到充分的记录。该研究的目的是确定这种变异的患者和医师的决定因素，并开发基于证据的决策辅助工具以帮助患者做出决策。 （2）风湿病患者的治疗依从性 - 我们正在进行一项前瞻性队列研究，以评估类风湿关节炎和全身性狼疮患者的治疗依从性。初步数据表明，依从性是有问题的。该研究的结果将为评估多方面干预以提高依从性提供基础。 （3）尽管技术成功，但总膝盖置换总膝关节替代的认知决定因素不满意结果。我们正在评估在接受膝盖替代的患者中，这种不满意的临床和社会心理决定因素。有证据表明，这可能与手术后三个月内的不足康复有关。在研究结束时，我们计划开发，实施和评估围手术期干预措施，旨在通过目标设定和各种其他认知技术来改善结果。 （4）膝关节骨关节炎患者对针灸反应的患者相互作用的影响 - 这是一项随机对照试验，比较针灸和假针刺治疗膝关节骨关节炎。该研究的主要目的是评估不同患者提供者的沟通方式对针灸和安慰剂反应的影响。