Impact of Alcohol Use on HIV Infection--In the United States and Russia

饮酒对艾滋病毒感染的影响——在美国和俄罗斯

• 批准号: 7062289
• 负责人: JEFFREY H. SAMET
• 金额: $ 15.15万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7062289
• 关键词: Commonwealth of Independent States; HIV infections; United States; alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; cardiovascular disorder risk; clinical research; coronary disorder; drug abuse; high risk behavior /lifestyle; human data; human subject; longitudinal human study; patient oriented research; sex behavior; statistics /biometry; substance abuse epidemiology; substance abuse related behavior; virus load

DESCRIPTION (provided by applicant): This proposal describes a career development plan encompassing patient-oriented research in the area of alcohol use and HIV infection, mentorship of junior clinical investigators, and skills advancement regarding the translation of research into public health policy. The applicant is an experienced clinical researcher in the fields of substance abuse and HIV who has demonstrated commitment and the ability to conduct high quality patient-oriented research and to train clinical investigators. The mentorship plan includes working primarily with fellows, junior physician faculty, and Russian faculty to develop patient-oriented research skills. The applicant's skills development plan includes studying effective methods of translating research into pragmatic public policy pertaining to enhanced care of patients who use alcohol and are infected or at risk of infection with HIV. The research planned in this proposal explores consequences of alcohol use in HIV-infected and at-risk patients. To assist mentorship efforts and the candidate's skills development, this research plan takes advantage of 3 current studies addressing HIV and alcohol use: HIV - Longitudinal Interrelationships of Viruses and Ethanol (HIV-LIVE) (NIAAA R01-AA13766); Russian Partnership to Reduce the Epidemic Via Engagement in Narcology Treatment (Russian PREVENT) (NIAAA R21-AA14821); and the Veterans Aging Cohort Study (VACS) (RO1-NIAAA,NIA,OAR). Two specific proposed projects are described in detail: investigation of cardiovascular consequences of HIV infection and alcohol use and alcohol's impact on sex and drug risk behaviors in a Russian cohort with alcohol problems. Two additional potential projects are also briefly presented concerning neurological consequences of HIV infection and alcohol use and HIV prevention in Russian HIV-infected persons with risky alcohol use. The effort committed to this career development award will enable the applicant to advance the following long-term goals: to develop clinical researchers from Boston University and Pavlov State Medical University in St Petersburg, Russia; to examine the impact of alcohol use on patients with and at risk for HIV infection; and to impact public health policy to better care for patients with or at risk for HIV infection who use alcohol.

描述（由申请人提供）：该提案描述了一项职业发展计划，包括酒精使用和艾滋病毒感染领域以患者为导向的研究、初级临床研究人员的指导以及将研究转化为公共卫生政策的技能提升。申请人是药物滥用和艾滋病毒领域经验丰富的临床研究人员，他表现出承诺和能力进行高质量的以患者为导向的研究并培训临床研究人员。指导计划主要包括工作 与研究员、初级医师教师和俄罗斯教师合作，培养以患者为导向的研究技能。申请人的技能发展计划包括研究有效的方法，将研究成果转化为务实的公共政策，以加强对酗酒且感染艾滋病毒或有感染艾滋病毒风险的患者的护理。该提案中计划的研究探讨了艾滋病毒感染者和高危患者饮酒的后果。为了协助辅导工作和候选人的技能发展，该研究计划利用了 3 项当前有关艾滋病毒和酒精使用的研究：艾滋病毒 - 病毒和乙醇的纵向相互关系 (HIV-LIVE) (NIAAA R01-AA13766)；俄罗斯通过参与麻醉品治疗减少流行病的伙伴关系（俄语 PREVENT）（NIAAA R21-AA14821）；以及退伍军人老龄化队列研究 (VACS) (RO1-NIAAA、NIA、OAR)。详细描述了两个具体的拟议项目：调查艾滋病毒感染和饮酒对心血管的影响，以及酒精对有酗酒问题的俄罗斯人群中性行为和吸毒风险行为的影响。还简要介绍了另外两个潜在项目，涉及艾滋病毒感染和饮酒的神经系统后果以及俄罗斯艾滋病毒感染者危险饮酒的艾滋病毒预防。致力于该职业发展奖的努力将使申请人能够推进以下长期目标：培养波士顿大学和俄罗斯圣彼得堡巴甫洛夫国立医科大学的临床研究人员；检查饮酒对艾滋病毒感染者和有感染风险的患者的影响；影响公共卫生政策，以更好地照顾饮酒的艾滋病毒感染者或有感染艾滋病毒风险的患者。