Transcriptional regulators of dendrite development

树突发育的转录调节因子

• 批准号: 6892306
• 负责人: JAY Z PARRISH
• 金额: $ 4.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6892306
• 关键词: Drosophilidae; RNA interference; biological models; biological signal transduction; cell type; dendrites; developmental neurobiology; embryo /fetus; genetic regulation; genetic transcription; morphology; peripheral nervous system; phenotype; postdoctoral investigator; transcription factor

DESCRIPTION (provided by applicant): Because dendrite development has not yet been extensively studied, a number of fundamental questions about dendrite development still need to be answered. The studies described below will focus on the following two questions: (1) What factors control the distinct morphology of a given class of dendrites? (2) Do distinct factors or signal transduction pathways regulate different aspects of dendrite development? Since transcription factors are likely regulators of multiple aspects of dendrite development and the Drosophila PNS is an attractive model system for genetic analysis of dendrite development I will study transcriptional regulation of dendrite development using Drosophila as a model system. Importantly, the Drosophila PNS is composed of multiple classes of neurons with distinct characteristic dendritic branching patterns so these studies should facilitate identification of factors which specify dendrite development in a cell type-specific fashion.

描述（由申请人提供）：由于枝晶发育尚未得到广泛研究，因此仍然需要回答有关枝晶发育的许多基本问题。下面描述的研究将集中在以下两个问题：（1）哪些因素控制给定类别树突的独特形态？ (2) 不同的因素或信号转导途径是否调节树突发育的不同方面？由于转录因子可能是树突发育多个方面的调节因子，并且果蝇 PNS 是树突发育遗传分析的一个有吸引力的模型系统，因此我将使用果蝇作为模型系统来研究树突发育的转录调控。重要的是，果蝇 PNS 由具有不同特征树突分支模式的多类神经元组成，因此这些研究应有助于识别以细胞类型特异性方式指定树突发育的因素。