Genetic Correlates of Alcohol Use Disorders

酒精使用障碍的遗传相关性

• 批准号: 6968214
• 负责人: LARA A. RAY
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6968214
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; alleles; behavioral genetics; clinical research; craving; cues; disease /disorder proneness /risk; gamma aminobutyrate; gene expression; genetic markers; genetic susceptibility; human subject; personality; predoctoral investigator; questionnaires; reporter genes; single nucleotide polymorphism; substance abuse epidemiology; substance abuse related behavior; young adult human (21-34)

DESCRIPTION (provided by applicant): This application proposes a laboratory study designed to test the association between two trait markers for alcohol use disorders (i.e., cue elicited craving and acute responses to alcohol) and two candidate polymorphisms linked to these trait markers (i.e., DRD4 VNTR and GABA Pro385/Ser SNP). Specifically, this proposal will: (1) test the relationship between the DRD4 VNTR polymorphism and cue elicited craving for alcohol; (2) investigate personality factors that may mediate the relationship between craving for alcohol and the DRD4 candidate gene; and (3) test the association between the GABA Pro385/Ser SNP and one's sensitivity to the effects of alcohol. We will compare 40 individuals with the DRD4 VNTR risk allele against 40 individuals without it in an alcohol challenge paradigm. Likewise, our matched research design will include 40 individuals with GABA risk Pro/Ser substitution and 40 individuals without it. We expect individuals with the risk alleles to score higher on measures of craving for alcohol (DRD4 VNTR) and lower on measures of sensitivity to the acute physiological and subjective effects of alcohol (GABA Pro/Ser SNP). The long term objective of this proposal is to advance our understanding of the genetic, biological, and behavioral determinants of alcohol addiction by utilizing a highly controlled laboratory design to test preliminary genetic findings.

描述（由申请人提供）：本申请提出了一项实验室研究，旨在测试两个用于酒精使用障碍的特征标记物（即提示引起的渴望和对酒精的急性反应）和两个与这些特征标记有关的候选多态性（即，即，是，即，即，即，即，即，即，即，即，也就是说。 DRD4 VNTR和GABA Pro385/Ser SNP）。具体而言，该提案将：（1）测试DRD4 VNTR多态性和提示之间的关系引起了对酒精的渴望； （2）研究可能介导渴望酒精与DRD4候选基因之间关系的人格因素； （3）测试GABA Pro385/Ser SNP与酒精影响的敏感性之间的关联。我们将在酒精挑战范式中与40个具有DRD4 VNTR风险等位基因的人与40个人进行比较。同样，我们匹配的研究设计将包括40个具有GABA风险/Ser替代的人和40个没有它的人。我们期望具有风险等位基因的人在渴望酒精（DRD4 VNTR）的措施上得分更高，并且对酒精急性生理和主观影响的敏感性（GABA PRO/SER SER SNP）的敏感度较低。该提案的长期目标是通过利用高度控制的实验室设计来测试初步的遗传发现，以提高我们对酒精成瘾遗传，生物学和行为决定因素的理解。